Susceptibility to and severity of tuberculosis infection in mice depends upon MHC-II-determined level of activation-inhibition balance in CD4 T-cells
Previously we have shown that H2-congenic recombinant mice of the B6.I-9.3 (H2-Ab1j) strain are significantly more susceptible to tuberculosis (TB) infection compared to their C57BL/6 (B6, H2-Ab) ancestors. Impaired TB control was characterized by decr…