Pan, J., Yuan, X., Yu, H., Liu, Z., Chen, S., Zhu, F., Shang, Y., Hong, S., Han, X., Zhu, Z., Jin, T., Pan, Y., Zhou, S.

Igniting cold tumors: reprogramming the tumor immune microenvironment with dual-payload ADCs in combination with PD-L1 -1BB bispecific antibodies

3 de June de 2026 by Pan, J., Yuan, X., Yu, H., Liu, Z., Chen, S., Zhu, F., Shang, Y., Hong, S., Han, X., Zhu, Z., Jin, T., Pan, Y., Zhou, S.

Background
The immunologically “cold” microenvironment of triple-negative breast cancer presents a major obstacle to treatment, conferring resistance to current immunotherapies. Targeting the stimulator of interferon genes (STING) pathway has emerged …