Qi, C., Liu, D., Liu, C., Wei, X., Ma, M., Lu, X., Tao, M., Zhang, C., Wang, X., He, T., Li, J., Dai, F., Ding, Y., Shen, L.

Antigen-independent activation is critical for the durable antitumor effect of GUCY2C-targeted CAR-T cells

4 de October de 2024 by Qi, C., Liu, D., Liu, C., Wei, X., Ma, M., Lu, X., Tao, M., Zhang, C., Wang, X., He, T., Li, J., Dai, F., Ding, Y., Shen, L.

Background
Chimeric antigen receptor (CAR)-T cells face many obstacles in solid tumor therapy, including heterogeneous antigen expression and inefficient T cell persistence. Guanylyl cyclase C (GUCY2C) has been identified as a suitable tumor antigen f…