TP53 loss attenuates C1q-associated macrophage remodeling in early adenomatous polyps in a porcine FAP model
BackgroundFamilial adenomatous polyposis (FAP) is a hereditary condition that almost invariably leads to colorectal cancer. While TP53 inactivation is well established as a late event in the adenoma-to-carcinoma sequence, its functional role during the…