2-5A is an immunotransmitter that fuels RNase L immunity
cGAS-cGAMP-STING and OAS-2-5A-RNase L are evolutionarily convergent innate immune pathways. cGAMP acts as an immunotransmitter; what about 2-5A? In this issue of Immunity, Huai et al. map the transfer of 2-5A between cells, establishing it as a bona fi…