Sun, Z., Shi, M., Xia, J., Li, X., Chen, N., Wang, H., Gao, Z., Jia, J., Yang, P., Ji, D., Gu, J.

HDAC and MEK inhibition synergistically suppresses HOXC6 and enhances PD-1 blockade efficacy in BRAFV600E-mutant microsatellite stable colorectal cancer

12 de January de 2025 by Sun, Z., Shi, M., Xia, J., Li, X., Chen, N., Wang, H., Gao, Z., Jia, J., Yang, P., Ji, D., Gu, J.

Background
B-Raf proto-oncogene, serine/threonine kinase (BRAF)V600E-mutant microsatellite stable (MSS) colorectal cancer (CRC) constitutes a distinct CRC subgroup, traditionally perceived as minimally responsive to standard therapies. Recent clinical…