pAc/Emm55 increases anti-melanoma immunity via TLR2 signaling in dendritic cells and improves checkpoint blockade efficacy
BackgroundpAc/Emm55 (IFx-Hu2.0) is a plasmid DNA therapy encoding a Streptococcus pyogenes-derived bacterial gene. It shows anti-tumor activity in preclinical models, but the mechanisms of anti-melanoma immunity and additive effects with immune checkpo…