Case Report: Interleukin-23 blockade achieves sustained remission in Niemann–Pick type C-associated Crohn’s disease refractory to anti-tumor necrosis factor therapy
BackgroundNiemann–Pick type C (NPC) is a lysosomal lipid trafficking disorder that is associated with defective autophagy and impaired bacterial clearance, potentially predisposing patients to Crohn’s disease (CD)-like granulomatous enteritis. Tumor ne…