BackgroundAcute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in children. Patients with high-risk ALL have a poor prognosis, and allogeneic hematopoietic stem cell transplantation (HSCT) is one of the important treatm…
BackgroundFIGO stage IVA cervical cancer is frequently associated with extensive pelvic organ invasion and high treatment complexity. In selected patients with severe hemorrhage, renal dysfunction, or poor baseline condition, delivery of standard thera…
Anti-myeloperoxidase (anti-MPO) antineutrophil cytoplasmic antibodies-associated vasculitis (AAV) manifests histologically as pauci-immune crescentic glomerulonephritis. Recurrent anti-MPO AAV after transplantation is rare and poorly understood. In thi…
Waldenström macroglobulinemia (WM) is a rare indolent B-cell lymphoma, characterized by lymphoplasmacytic infiltration of bone marrow and the existence of monoclonal IgM in circulation. Renal AL amyloidosis is an uncommon complication of WM, and its tr…
BackgroundAutoimmune glial fibrillary acidic protein (GFAP) astrocytopathy is an autoimmune inflammatory disorder of the central nervous system associated with GFAP-IgG. It most commonly presents as meningoencephalitis, myelitis, or meningoencephalomye…
Inborn defects of the alternative pathway (AP) of the complement system have revealed its essential role in host defense against invasive infections caused by encapsulated bacteria. Biallelic pathogenic variants in the CFB gene cause complement factor …
IntroductionImmune checkpoint inhibitors (ICIs) have transformed the therapeutic landscape of advanced non-small cell lung cancer (NSCLC), offering durable survival in selected patients. However, ICIs can induce immune-related adverse events (irAEs), a…
BackgroundImmunotherapy with checkpoint inhibitor (ICI) has revolutionized the treatment of cancer including squamous cell carcinoma. Nevertheless, there is an unmet need to gain a better understanding of the effect of these therapies on pregnancy and …
Immune checkpoint inhibitor-associated myocarditis, myositis, and myasthenia gravis overlap syndrome (IM3OS) is an uncommon immune-related adverse event (irAE) associated with the use of immune checkpoint inhibitors for the treatment of malignancies. W…
Pyoderma gangrenosum is a rare autoimmune condition that is difficult to diagnose and primarily affects the skin. Extracutaneous manifestations, including hepatic involvement, occur only rarely. Here, we report a case of extracutaneous manifestation of…
