Immune checkpoint inhibitors (ICIs) have been widely utilized in patients with cancer and established as a standard therapeutic modality for various solid tumors. Although generally well tolerated, ICIs can induce unique immune-related adverse events (…
This article reports a rare immune-related cutaneous adverse event (ircAE) manifesting as nasal swelling and ulceration in a patient with small cell lung cancer (SCLC) after treatment with atezolizumab. A patient with extensive-stage SCLC developed sym…
BackgroundALK-positive histiocytosis is a rare form of cutaneous histiocytosis and has been explicitly designated as a novel histiocytic neoplasm in recent classification systems. This disease may involve multiple organs throughout the body. Its diagno…
Systemic lupus erythematosus (SLE) frequently involves the hematologic system, and autoimmune hemolytic anemia (AIHA) is a severe and potentially life-threatening complication. Splenectomy has been regarded as a third-line treatment option for refracto…
BackgroundAntigen escape and PD-L1/PD-1 axis-mediated immunosuppression in the tumor microenvironment (TME) are the predominant drivers of treatment failure in adult patients with relapsed/refractory (R/R) B-cell acute lymphoblastic leukemia (B-ALL). C…
IntroductionHermansky–Pudlak syndrome (HPS) is a rare autosomal recessive disorder characterized by oculocutaneous albinism (OCA), ocular nystagmus, bleeding diathesis and, in certain forms, pulmonary fibrosis (PF). We report a case of genetically conf…
Antisynthetase syndrome (ASS) is a systemic autoimmune disorder classified as a subtype of the idiopathic inflammatory myopathies (IIM). The condition is defined by the presence of mutually exclusive autoantibodies directed against an aminoacyl-tRNA sy…
Transplantation-associated thrombotic microangiopathy (TA-TMA) is a severe complication following hematopoietic stem cell transplantation, with its pathogenesis not yet fully understood and a lack of highly effective treatment options currently availab…
BackgroundUveal melanoma (UM) is a rare intraocular malignancy with limited systemic treatment options and poor outcomes once metastatic. Tebentafusp, an ImmTAC (Immune-mobilizing monoclonal T-cell receptor Against Cancer) targeting gp100 in HLA-A*02:0…
Recent research has explored the potential of using neoadjuvant dual immune checkpoint inhibitors (ICIs) combined with de−escalated chemotherapy in several locally advanced tumors to determine if such a combined regimen can enhance tumor response while…
