Wang, L., Gong, S., Wang, J., Bao, Y., Mei, N., Lu, X., Chen, W., Xi, L., Zhang, H., Chen, X., Ning, P., Fan, X., Wang, H.

Enhanced CD33 CAR-NK cells secreting anti-CD73scFv overcome adenosine-mediated immunosuppression and improve anti-AML efficacy

1 de September de 2026 by Wang, L., Gong, S., Wang, J., Bao, Y., Mei, N., Lu, X., Chen, W., Xi, L., Zhang, H., Chen, X., Ning, P., Fan, X., Wang, H.

Background
Acute myeloid leukemia (AML) is an aggressive hematologic malignancy with dismal outcomes, especially in relapsed/refractory settings. Chimeric antigen receptor natural killer (CAR-NK) cell therapy holds promise but is constrained by the im…