Wu, J., Zhai, J., Lv, L., Zhang, Y., Shen, Y., Qu, Q., Chen, C.

Sequential involvement of hypoxia and anti-PD-1 treatment in shaping tumor-regional CD39+CD8+ T cells highlights immunotherapy-resistant features in NSCLC

25 de June de 2026 by Wu, J., Zhai, J., Lv, L., Zhang, Y., Shen, Y., Qu, Q., Chen, C.

Background
Understanding resistance to anti-programmed cell death protein 1 (PD-1) therapy is critical for developing reversal strategies. Although ectonucleotidase CD39 (ENTPD1) (CD39)+ cluster of differentiation 8 (CD8)+ T cells have been associated…