The TCR-SUB1-DOCK2 axis promotes autoimmunity by driving pathogenic CD4+ T cell tissue infiltration
Blocking pathogenic T cell migration is crucial for treating autoimmune diseases. Li et al. reveal SUB1 as a gatekeeper of CD4+ T cell infiltration in autoimmunity. TCR-induced SUB1 drives Rac-dependent cytoskeletal remodeling via DOCK2 transcriptional…