Xu, Z., Liu, L., Jiang, W., Qiu, Y., Zhang, B., Cheng, J., Luo, J., Guo, J., Xu, J.

VHL missense mutation delineate aggressive clear cell renal cell carcinoma subtype with favorable immunotherapeutic response

24 de October de 2024 by Xu, Z., Liu, L., Jiang, W., Qiu, Y., Zhang, B., Cheng, J., Luo, J., Guo, J., Xu, J.

Background
von Hippel-Lindau (VHL) harbors the highest mutational frequency in clear cell renal cell carcinoma (ccRCC). Although VHL mutational subtypes exert diverse impacts on the functionality of the VHL protein, the clinical significance of VHL mu…