Tyrosine phosphatase PTPN11/SHP2 in solid tumors – bull’s eye for targeted therapy?
Encoded by PTPN11, the Src-homology 2 domain-containing phosphatase 2 (SHP2) integrates signals from various membrane-bound receptors such as receptor tyrosine kinases (RTKs), cytokine and integrin receptors and thereby promotes cell survival and proli…