Single-cell profiling deciphering cholesterol metabolism dysregulation in metastatic uveal melanoma and implicating SLC45A2 in its prognosis
IntroductionUveal melanoma (UM) is the most common primary intraocular malignancy in adults, characterized by high metastatic potential, primarily to the liver. UM exhibits unique molecular drivers, such as GNAQ/GNA11 mutations, and a distinct immune m…