Androgens help monocytes deliver pain relief
Nature Reviews Immunology, Published online: 05 March 2026; doi:10.1038/s41577-026-01287-1Androgens support IL-10-expressing monocytes that alleviate inflammatory pain.
Yvonne Bordon
Gut macrophages and Parkinson’s disease
Nature Reviews Immunology, Published online: 11 February 2026; doi:10.1038/s41577-026-01281-7Intestinal macrophages that support the enteric nervous system may be involved in the spread of α-synuclein pathology from the gut to the brain.
Albumin protects against deadly fungal infection
Nature Reviews Immunology, Published online: 12 January 2026; doi:10.1038/s41577-026-01270-wSerum albumin binds and prevents the oxidation of free fatty acids, which then prevent the expression of virulence factors in Mucorales fungi.
Parental allergy and early life infection combine to promote asthma in childhood
Nature Reviews Immunology, Published online: 09 December 2025; doi:10.1038/s41577-025-01257-zRespiratory infections in early life combine with genetic and maternal factors to drive asthma development in childhood.
Butyrate promotes T cell ‘stemness’ to support immunity to melanoma
Nature Reviews Immunology, Published online: 14 November 2025; doi:10.1038/s41577-025-01245-3Short-chain fatty acids generated by the gut microbiota can support T cell ‘stemness’ and lead to improved cancer immunotherapy outcomes.
Autoimmune T cells identified in ALS
Nature Reviews Immunology, Published online: 08 October 2025; doi:10.1038/s41577-025-01233-7Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL…
Regulatory KIR<sup>+</sup>CD8<sup>+</sup> T cells in pregnancy
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus.
Exercise induces metabolic changes in the gut microbiota that enhance anti-tumour T cell responses
Nature Reviews Immunology, Published online: 28 July 2025; doi:10.1038/s41577-025-01217-7Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses.
Fatty liver disease induced by maternal obesity is driven by metabolic rewiring of Kupffer cells
Nature Reviews Immunology, Published online: 30 June 2025; doi:10.1038/s41577-025-01205-xMaternal obesity during pregnancy promotes a form of fatty liver disease in offspring that is dependent on HIF1α-mediated rewiring of Kupffer cell…
Cytokines target distinct brain areas to modulate behavioural responses
Nature Reviews Immunology, Published online: 29 April 2025; doi:10.1038/s41577-025-01179-wTwo new studies describe populations of neurons in distinct brain regions that respond to IL-17 family cytokines and IL-10 to regulate social and…