Yvonne Bordon Nature Reviews Immunology, Published online: 08 October 2025; doi:10.1038/s41577-025-01233-7Amyotrophic lateral sclerosis is associated with CD4+ T cells that are specific for the C9orf72 autoantigen and preferentially produce IL-4, IL…
Nature Reviews Immunology, Published online: 01 September 2025; doi:10.1038/s41577-025-01225-7Populations of regulatory KIR+CD8+ T cells expand during pregnancy and can promote maternal tolerance to the developing fetus.
Nature Reviews Immunology, Published online: 28 July 2025; doi:10.1038/s41577-025-01217-7Exercise promotes changes in the gut microbiota that enhance anti-tumour T cell responses.
Nature Reviews Immunology, Published online: 30 June 2025; doi:10.1038/s41577-025-01205-xMaternal obesity during pregnancy promotes a form of fatty liver disease in offspring that is dependent on HIF1α-mediated rewiring of Kupffer cell…
Nature Reviews Immunology, Published online: 29 April 2025; doi:10.1038/s41577-025-01179-wTwo new studies describe populations of neurons in distinct brain regions that respond to IL-17 family cytokines and IL-10 to regulate social and…
Nature Reviews Immunology, Published online: 09 April 2025; doi:10.1038/s41577-025-01170-5Neutrophils not only kill invading microorganisms but also help to prevent their entry into tissues in the first place.
Nature Reviews Immunology, Published online: 17 March 2025; doi:10.1038/s41577-025-01160-7Drugs like aspirin can enhance the anti-metastatic activity of T cells by blocking a platelet-mediated pathway of suppression.
Nature Reviews Immunology, Published online: 12 February 2025; doi:10.1038/s41577-025-01144-7Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus fo…
Nature Reviews Immunology, Published online: 19 December 2024; doi:10.1038/s41577-024-01126-1A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN signalling.
Nature Reviews Immunology, Published online: 03 December 2024; doi:10.1038/s41577-024-01121-6Endogenous self-peptides derived from CNS antigens are presented on MHC class II molecules at the borders of the CNS and expand suppressive po…
