Nature Reviews Immunology, Published online: 12 February 2025; doi:10.1038/s41577-025-01144-7Loss of a conserved cis-regulatory element at HDAC9 increases NLRP3 inflammasome activation and may explain why HDAC9 is a major risk locus fo…

Nature Reviews Immunology, Published online: 19 December 2024; doi:10.1038/s41577-024-01126-1A transposon-derived isoform of the type I interferon (IFN) receptor IFNAR2 can serve as a decoy receptor to regulate IFN signalling.

Nature Reviews Immunology, Published online: 03 December 2024; doi:10.1038/s41577-024-01121-6Endogenous self-peptides derived from CNS antigens are presented on MHC class II molecules at the borders of the CNS and expand suppressive po…

Nature Reviews Immunology, Published online: 28 October 2024; doi:10.1038/s41577-024-01107-4Blocking the RNase activity of IRE1α can convert ‘cold’ tumours to immunologically ‘hot’ ones that respond to chemo-immunotherapy.

Nature Reviews Immunology, Published online: 24 September 2024; doi:10.1038/s41577-024-01096-4MICL regulates neutrophil responses by serving as an inhibitory pattern-recognition receptor for NETs.

Nature Reviews Immunology, Published online: 23 August 2024; doi:10.1038/s41577-024-01082-wOrganoids generated from individuals with coeliac disease identify a role for IL-7 in disease pathogenesis.

Nature Reviews Immunology, Published online: 24 July 2024; doi:10.1038/s41577-024-01071-zThe pyroptotic secretome can be beneficial in promoting tissue repair.

Nature Reviews Immunology, Published online: 10 June 2024; doi:10.1038/s41577-024-01055-zCAR T cell therapy alleviates type 2 airway inflammation in mouse models of asthma.

Nature Reviews Immunology, Published online: 08 May 2024; doi:10.1038/s41577-024-01042-4Commensal bacteria induce liver macrophages that protect the tissue against inflammation.

Nature Reviews Immunology, Published online: 09 April 2024; doi:10.1038/s41577-024-01031-7Depletion of myeloid-biased haematopoietic stem cells can mitigate age-associated immune dysfunction.