Zhou, J.-E., Hu, Y., Chen, Y., Liu, J., Gao, Y., Dai, X., Wang, H., Yu, L., Xu, N., Xiao, J., Yan, Z., Sun, L., Li, F., Chen, C.

In situ generation of proinflammatory CAR macrophages via mRNA-TLR agonist co-delivery for triple-negative breast cancer immunotherapy

28 de July de 2026 by Zhou, J.-E., Hu, Y., Chen, Y., Liu, J., Gao, Y., Dai, X., Wang, H., Yu, L., Xu, N., Xiao, J., Yan, Z., Sun, L., Li, F., Chen, C.

Background
Chimeric antigen receptor (CAR) macrophage therapy shows significant potential for solid tumors owing to the intrinsic tumor infiltration and phagocytic capacity of macrophages. However, its clinical translation is limited by macrophage phe…