Zhu, M., Tang, W., Tang, X., Zhu, Z., Jiang, Y., Sarwar, A., Zhang, H., Chu, D., Zhang, Z., Zhang, Y.

Cantharidin overcomes IL-2R{alpha} signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species

14 de July de 2024 by Zhu, M., Tang, W., Tang, X., Zhu, Z., Jiang, Y., Sarwar, A., Zhang, H., Chu, D., Zhang, Z., Zhang, Y.

Background
Vorinostat (SAHA) is a histone deacetylase inhibitor that has shown clinical efficacy against advanced cutaneous T-cell lymphoma (CTCL). However, only a subset of patients with CTCL (30–35%) respond to SAHA and the response is not alw…