Cantharidin overcomes IL-2R{alpha} signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species
Background
Vorinostat (SAHA) is a histone deacetylase inhibitor that has shown clinical efficacy against advanced cutaneous T-cell lymphoma (CTCL). However, only a subset of patients with CTCL (30–35%) respond to SAHA and the response is not alw…