The coexistence of thymoma-associated multiorgan autoimmunity (TAMA) and Good’s syndrome creates a challenging clinical scenario in which autoimmunity and profound immunodeficiency occur simultaneously. Here, we report a 37-year-old female with invasiv…
Renal cancer is estimated to have accounted for 2.4% of all incident cancer cases worldwide in 2018. Renal cell carcinoma (RCC) is the most prevalent adult renal cancer, with the clear cell subtype accounting for 75-85% of cases and displaying pronounc…
Lupus mesenteric vasculitis (LMV) is a rare but potentially life-threatening complication of systemic lupus erythematosus, with reported mortality rates of up to 13.4% despite aggressive immunosuppression. Standard management relies on high-dose glucoc…
BackgroundInterstitial pneumonia with autoimmune features (IPAF) is an exclusionary diagnosis that requires the exclusion of alternative etiologies, including malignancy. Invasive mucinous adenocarcinoma (IMA) of the lung can radiologically and clinica…
BackgroundDrug reaction with eosinophilia and systemic symptoms (DRESS) is a severe delayed drug hypersensitivity reaction that may overlap with secondary hemophagocytic lymphohistiocytosis (HLH). Direct antiglobulin test (DAT)-positive hemolysis durin…
Anti-p200 pemphigoid is a rare autoimmune subepidermal blistering disease with limited evidence guiding its management. We report a 49-year-old woman with refractory anti-p200 pemphigoid who failed treatment with high-dose prednisone and dapsone and de…
Kawasaki disease (KD) is an acute systemic vasculitis that can affect multiple organs. Kawasaki disease shock syndrome (KDSS) is a severe complication of KD. Pulmonary involvement is uncommon in KD, and there are very few reports of patients with KD wh…
Bullous Pemphigoid (BP) is the most common autoimmune blistering disorder, predominantly affecting elderly patients and often requiring prolonged immunosuppression. Conventional therapies are frequently limited by adverse effects and incomplete disease…
Immune thrombocytopenia (ITP) is an autoimmune bleeding disorder characterized by immune-mediated platelet destruction and impaired platelet production. While pediatric ITP is often self-limited or responsive to first-line therapies, such as corticoste…
BackgroundInterleukin-17A (IL-17A) inhibitors are effective therapies for psoriasis (PsO) and psoriatic arthritis (PsA), yet they may induce or exacerbate inflammatory bowel disease (IBD). Vunakizumab is a novel humanized anti-IL-17A monoclonal antibod…
