Guillain–Barré syndrome (GBS) is a rare neurological disorder characterized by muscle weakness and paralysis. Although the exact etiology remains unclear, the current standard treatments include intravenous immunoglobulin (IVIG) and plasma exchange (PL…
We describe an atypical presentation of Immune dysregulation, Polyendocrinopathy, Enteropathy, X-linked syndrome. The patient exhibited food allergies and eczema, along with recurrent and severe infections, but notably lacked the hallmark chronic diarr…
In presensitized kidney transplantation with positive donor-specific antibody (DSA), the activation of immune memory responses leads to a significant increase in DSA levels, followed by early active antibody-mediated rejection (early aAMR). For some pa…
Guillain-Barré syndrome (GBS), the leading global cause of acquired neuromuscular paralysis, is classically defined as an immune-mediated polyradiculoneuropathy triggered by molecular mimicry between microbial antigens and peripheral nerve components. …
Cytokine-targeted biologics have revolutionized the management of moderate-to-severe psoriasis; however, all available therapies have failed a growing number of patients. Mesenchymal stromal cells (MSCs), with their immunomodulatory properties, offer a…
BackgroundHuman cytomegalovirus (HCMV) exhibits a high prevalence and is a major threat to immunocompromised individuals. Conventional diagnostic modalities are increasingly struggling to meet evolving clinical needs. Metagenomic next-generation sequen…
Crohn’s disease (CD) is a chronic inflammatory bowel disease that may include neurological complications, besides gastrointestinal manifestations. Although cerebrovascular complications are commonly reported, cerebral vasculitis remains an exceedingly …
Fabry disease (FD) is an X-linked lysosomal storage disease caused by a deficiency of the enzyme alpha-galactosidase (α-Gal). Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with multisystem involvement and predominantly affects wome…
BackgroundHypertrophic spinal pachymeningitis (HSP) and retroperitoneal fibrosis (RPF) are rare inflammatory disorders, often associated with immunoglobulin G4-related disease (IgG4-RD). This case underscores the diagnostic intricacies and therapeutic …
Primary cardiac lymphoma (PCL), an exceedingly rare and aggressive extranodal lymphoma confined to the heart and/or pericardium, poses significant diagnostic and therapeutic challenges with a historically dismal prognosis. We present the first document…
