Regulatory T cells (Tregs) play a central role in immune homeostasis and the preservation of immunological self-tolerance. Treg activity depends on prolonged IL-2 receptor (IL-2R) signaling, and impairment or loss of this function has been linked to th…
After primary infection with varicella, varicella-zoster virus (VZV) establishes a latent state that precedes the clinical manifestation of herpes zoster. Growing evidence, however, indicates that latency is not merely quiescent but represents an activ…
BackgroundOperational tolerance, defined as stable liver graft function without immunosuppression, has been observed in select transplant recipients. While immune regulatory mechanisms have been implicated, the biological processes underlying tolerance…
Damage-associated molecular patterns (DAMPs) cause sterile auto- inflammation after a traumatic incident in human tissues via innate immunity. The auto-reactivity of natural killer T cells (NK-T cells) instigated by DAMP-activated exocytosis of dendrit…
Donor lymphocyte infusions (DLI) are a standard therapy following allogeneic hematopoietic cell transplantation (alloHCT) for preventing and treating leukemic relapse in high-risk patients, particularly those with myeloid malignancies such as acute mye…
IntroductionMetastasis formation poses a significant challenge to oncologists, as it severely limits the survival of colorectal cancer (CRC) patients. Recently, we demonstrated that CD44 promotes spontaneous distant metastasis in a CRC xenograft model….
Despite decades of progress, long-term outcomes in human organ transplantation remain challenging. Functional decline in transplanted organs has stagnated over the past two decades, with most patients requiring lifelong immunosuppression, therapies tha…
Although some reports suggest that COVID-19 vaccination may exacerbate existing autoimmune diseases or trigger new-onset cases, a definitive causal relationship between the vaccines and these conditions has not been established. Several potential mecha…
Gating is a fundamental and essential process in cytometry data analysis since it defines cell types of interest. Currently, there is no universally accepted method for representing and sharing gating strategies among software, publications, and reposi…
The liver is susceptible to viruses and bacterial infections, tumors, and sterile tissue damage, but immunological danger recognition in the liver is highly unconventional. When analyzing innate and adaptive immunity in the organ, the valid concepts th…
