Non-small cell lung cancer (NSCLC) is frequently associated with sarcopenia, a debilitating condition of muscle wasting driven by complex tumor–muscle cross-talk. To unravel the regulatory mechanisms underlying this phenotype, we reconstructed a compre…
BackgroundThree convergent phenomena in biomedical research have lacked a unified mechanistic explanation: the dendritic cell dysfunction of aging, the immune evasion of cancer, and the tolerogenic bias of chronic infection. Each is characterized by fa…
Psoriasis is primarily characterized by interleukin-23/T helper 17 (IL-23/Th17)-related inflammation, but clinical and epidemiological observations also suggest recurrent temporal features, including seasonal fluctuation, nocturnal symptom exacerbation…
Thyroid hormone (TH) signaling is widely recognized as an important regulator of skeletal muscle regeneration, yet the mechanisms by which aging alters TH-dependent regenerative responses remain unresolved. Current models generally assume that age-asso…
Inflammaging is chronic low-grade inflammation arising from a progressive imbalance between pro-inflammatory and anti-inflammatory immune networks. The rate of inflammaging exhibits marked interindividual variation owing to differences in the pace of b…
Current models of microbiome, immune crosstalk center on extracellular receptor-mediated signaling, yet a critical observation challenges this paradigm: intracellular concentrations of gut-derived bacterial metabolites (GDBMs) in CD4+ T cells do not co…
Lichen sclerosus (LS) is a chronic inflammatory and fibrosing dermatosis with a well-documented autoimmune background and a dominant Th1/Th17-driven immune response. Despite growing insight into its immunopathogenesis, the mechanisms linking persistent…
An earlier publication suggested that elevated TGF-β1 together with IL-1β and IL-6 drives neutrophilic asthma, increases cancer risk, and is associated with metabolic dysregulation. This article examines how these cytokines shape the therapeutic effica…
Mast cell activation syndrome (MCAS) is characterized by pronounced heterogeneity, fluctuating severity, delayed post-perturbation crashes analogous to those documented in post-exertional malaise, and highly variable clinical trajectories that are poor…
BackgroundAllergic rhinitis (AR) is an underrecognized contributor to olfactory dysfunction (OD). Although smell loss in AR is commonly attributed to conductive obstruction, some patients exhibit persistent or disproportionate hyposmia despite improvem…
