Epilepsy is one of the most prevalent neurological disorders, affecting over 70 million individuals worldwide. However, despite the introduction of more than 30 anti-seizure medications over three decades, approximately 30% of patients continue to suff…
Chronic inflammatory and autoimmune conditions frequently manifest as multi-organ dysfunction without a single explanatory lens that integrates metabolic stress, innate immune activation, transcriptional control, and autonomic regulation. Here, we prop…
With ageing populations, the prevalence of different types of dementias is increasing. The pathology of Alzheimer’s disease (AD), the most common form of dementia, has been linked to the presence of plaques and neurofibrillary tangles in the central ne…
Radioresistant thymic cells encompass minor subsets of lymphoid precursors of T cells (TLPs), innate lymphoid cells (ILCs), as well as stromal-epithelial and endothelial populations. This review focuses on radioresistant TLPs and their regenerative and…
BackgroundCryoglobulinemia indicates the reversible, cold-dependent precipitation of immunoglobulins (Ig), which may be monoclonal (MoC) or mixed IgG–IgM (MC). Although this in vitro phenomenon is relatively frequent, only a minority of cases develop c…
The human immune system depends on microbial partners to maintain restraint. Short-chain fatty acids (SCFAs), produced by anaerobic fermenters in the gut, mouth, and skin, act as biochemical “peace signals” that calm immune activation and promote toler…
Adjuvants have been indispensable in vaccinology, enhancing immunogenicity, shaping adaptive immune polarization, and extending the durability of protective responses. Classical adjuvants, including alum, oil-in-water emulsions, liposomal formulations,…
Diverse Igh repertoires require successful V(D)J recombination allowing B cell receptor expression and Ig secretion for humoral immune responses. Igh locus contraction has been implicated in generating spatial proximity between distal VH segments and t…
Plasmacytes, the effector arm of humoral immunity, produce sufficient amounts of specific antibodies to provide protection against infection or disease. The durability of this humoral protection depends on the generation of long-lived plasmacytes (LLPC…
The specificity of the immune response is critical to its biological function, yet the generality of immune recognition implies that antibody binding is multispecific or degenerate. The current work explores and quantifies this paradox through a system…
