Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by persistent synovial inflammation, progressive cartilage destruction, and irreversible bone erosion. Although substantial progress has been made in identifying downstream inflamm…
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic, symmetric polyarticular synovitis, with a global prevalence of approximately 0.5%-1%. Its pathogenesis involves a complex interplay of genetic and environmental factor…
Therapeutic antibodies are widely used in cancer biotherapy due to their target specificity, mediating tumor cell inhibition, angiogenesis suppression, and immune modulation. However, systemic administration often leads to off-target effects, as many a…
Depression is a prevalent neuropsychiatric disorder with high incidence and causing severe disability, representing a clinically unmet challenge and thus demanding more effective therapeutics. Neuroinflammation in the central nervous system (CNS) is a …
Oral microbiome imbalance is involved in the development of head and neck cancers (HNCs). There is a group of oral pathogens, such as Porphyromonas gingivalis, Tannerella forsythia, and Treponema denticola, that creates red-complex. Currently, the oral…
Myopia has become a global public health challenge, with pathological high myopia leading to irreversible visual impairment. Accumulating evidence suggests that chronic inflammation is closely associated with scleral remodeling and axial elongation, th…
Regulatory T cells (Tregs) play a central role in maintaining immune homeostasis. Therefore, owing to their unique immunomodulatory function, their adoptive transfer has been investigated as a novel therapeutic modality. Recent progress in cell manufac…
Menopause is a significant risk factor for dry eye disease (DED), conventionally explained by estrogen deficiency and diminished tear production. Recent evidence, however, highlights the pivotal role of immune-inflammatory mechanisms in its development…
Glutaminyl-peptide cyclotransferase (QPCT, QC) and its isoenzyme glutaminyl-peptide cyclotransferase-like protein (QPCTL, isoQC) are zinc-dependent enzymes that post-translationally catalyze the conversion of N-terminal glutamine or glutamate residues …
BackgroundAtherosclerosis (AS), the pathological basis of cardiovascular diseases, is a major cause of global mortality. Gut microbiota dysbiosis contributes to AS progression via trimethylamine N-oxide (TMAO), inflammation, and vascular dysfunction. P…
