Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by immune dysregulation and multiorgan inflammation. T-cell metabolic reprogramming has recently emerged as an active area of investigation in the pathogenesis of SLE. Thi…
Metabolic disturbances contribute to osteoarthritis through mechanisms that extend beyond increased mechanical loading, yet their effects on inflammatory resolution remain incompletely understood. Macrophage efferocytosis—the recognition, engulfment, a…
Anaerobic central nervous system (CNS) infections are uncommon but diagnostically difficult because fastidious organisms may be suppressed by empirical antimicrobial therapy and conventional cultures may remain negative. Cerebrospinal fluid (CSF) metag…
Glioblastoma (GBM) remains the most lethal primary brain tumor, with survival still limited despite advances in multimodal treatment. The tumor’s profound heterogeneity–across patients, within individual tumors, and over time–has frustrated every cla…
Leukocyte entry into the retina involves more than increased vascular permeability. This mini review synthesizes predominantly murine experimental evidence for a proposed retinal venular immune gate; the model has not been validated in the human retina…
Recurrent implantation failure (RIF) describes a clinical outcome rather than a single diagnosis or immune disorder. During progesterone-driven decidualization, changes in stromal metabolism and epithelial secretion accompany the production of signals …
Psoriasis is a chronic inflammatory skin disease driven by the IL-23/IL-17 axis. Evidence accumulated over the past decade indicates that its pathogenesis extends beyond the skin and involves bidirectional communication between the intestinal microbiot…
Saliva is non-invasive, repeatable, and anatomically close to oral squamous cell carcinoma (OSCC), but proximity does not establish that a salivary biomolecule originates from the tumor. Cytokines, extracellular vesicles, coding and non-coding RNAs, an…
Pathogenic neuronal-surface autoantibodies can disrupt extracellular receptors, ion-channel complexes, and synaptic proteins, yet their regional neurological phenotypes differ substantially. This variability is particularly informative in the cerebellu…
Extracellular vesicles (EVs) are emerging cell-free therapeutic platforms for cutaneous wound repair that regulate diverse cellular processes, including intercellular communication, inflammation, angiogenesis, extracellular matrix remodeling, and tissu…
