BackgroundOvarian cancer (OC) is a leading cause of cancer-related death among women, with elevated levels of stress hormones linked to OC progression and immune evasion in the tumor microenvironment (TME). Chronic psychosocial stress has been associat…
BackgroundThis study aimed to develop and validate an interpretable machine learning model that harnesses circulating tumor DNA (ctDNA) to predict progression-free survival (PFS) in patients with non-small cell lung cancer (NSCLC) undergoing immunother…
BackgroundLipocalin-2 (Lcn2) is a sensitive early marker for acute kidney injury, delayed graft function and acute rejection of kidney transplants. We previously showed the renoprotective effect of recombinant Lcn2:Siderophore: Fe3+ (rLcn2) in a mouse …
Virus-specific CD4+ T cells typically undergo T helper (Th) 1 differentiation and contribute to a type 1 immune response in infection with lymphocytic choriomeningitis virus (LCMV). Using this model pathogen, we performed an in-depth analysis of the qu…
BackgroundT cells play a crucial role in the adaptive immune response against acute virus infections. The extensive diversity of T cell receptors (TCRs) presents a complex challenge for understanding its implications in immune responses. Investigating …
IntroductionMicrosatellite stable colorectal cancer (MSS-CRC) is referred to as an immune desert-type tumor. Emerging studies have demonstrated that inhibition of the Wnt/β-catenin pathway can enhance the anti-tumor immune response. This research focus…
BackgroundTriple-negative breast cancer (TNBC) remains a challenging malignancy with limited therapeutic options and variable responses to immune checkpoint inhibitors (ICIs). The tumor immune infiltration significantly influences the outcomes of immun…
Checkpoint inhibitors targeting the PD-1/PD-L1 axis have revolutionized cancer immunotherapy, yet response rates remain limited. To enhance efficacy, next-generation approaches target T cell-activating cytokines to PD-1 via antibodies. The goal is simu…
BackgroundTriple-seronegative (Triple-SN) myasthenia gravis (MG) is a subtype of MG, and its diagnosis and treatment are challenging. Our study aims to discover new biomarkers and potential therapeutic targets and explore the preliminary mechanisms of …
BackgroundPatients with rheumatoid arthritis (RA) frequently experience increased physical pain and impaired self-perception. However, the combined impact of the pan-immune-inflammation value (PIV) and the visual analogue scale (VAS), representing subj…
