ObjectiveThis study aims to elucidate the molecular regulatory mechanisms of Chitinase-3-like protein 1 (CHI3L1) in rheumatoid arthritis (RA) and its association with disease activity, focusing on its translational potential in RA diagnosis, dynamic mo…
IntroductionObesity is increasing globally, and it negatively impacts influenza vaccine efficacy. Although sex differences in influenza vaccine responses are studied in non-obese hosts, studies investigating sex differences in influenza vaccine-induced…
IntroductionInotuzumab ozogamicin is increasingly being used as bridging therapy (BT) prior to chimeric antigen receptor T-cell (CAR-T) in relapsed/refractory B-cell acute lymphoblastic leukemia (R/R ALL), but its impact on CAR-T expansion and clinical…
Elimination of latently and persistently HIV-infected cells is one of the main barriers to finding a cure for HIV. We have demonstrated that cells latently/persistently infected with HIV impair interferon signaling, which makes them susceptible to sele…
IntroductionEarly-life dysbiosis is associated with increased risk of asthma development but the underlying mechanisms remain unclear. Although eosinophils have been reported in the developing lung, their contributions to alveolar morphogenesis and lun…
PurposeThis study aimed to delineate critical factors, particularly immune-inflammatory biomarkers, that predict therapeutic response and overall survival (OS) in non-small cell lung cancer (NSCLC) patients with brain metastases (BM) undergoing stereot…
IntroductionRecombinant allergens are an important diagnostic tool for determining the IgE-sensitization profile of patients, assessing the risk of symptom severity and potential clinical cross-reactivity. In this context, the use of different host cel…
IntroductionChimeric antigen receptor T (CAR-T) cell therapies have demonstrated remarkable success in treating relapsed and refractory (R/R) B-cell hematological malignancies. Although the application of CAR-T therapy in acute myeloid leukemia (AML) i…
IntroductionWe previously reported that opioid use disorder (OUD) heightens inflammation in people with HIV (PWH). Underlying inflammation is considered to be detrimental to immune responses to influenza vaccine in PWH. Here, we tested the hypothesis t…
BackgroundThe prognosis of patients with cancer in which tumor-associated macrophages with a pro-tumoral phenotype are abundant is poor. This includes aggressive forms of non-medullary thyroid carcinoma (NMTC). Trained immunity describes long-term epig…
