BackgroundCoccidiosis, caused by Eimeria species, is a major enteric disease in birds, with Eimeria labbeana-like isolates frequently inducing severe intestinal lesions, diarrhea, and reduced weight gain in pigeons. Conventional anticoccidial drugs fac…
BackgroundPrimary angiitis of the central nervous system (PACNS) is a rare immune-mediated vasculitis with distinct subtypes (large/medium-vessel [LV-PACNS] and small-vessel [SV-PACNS]). This study aims to provide evidence-based data from the Chinese p…
BackgroundDiabetic nephropathy (DN) is one of the vascular complications of diabetes and a leading cause of end-stage renal disease (ESRD) and mortality in diabetic patients. PANoptosis has been defined a unique form of programmed cell death that integ…
Neoantigen-based vaccines represent a promising approach in cancer immunotherapy, with the key to their effective clinical application lying in the precise identification of immunogenic neoantigens. Existing methods primarily focus on genomic variation…
BackgroundChronic antibiotic-refractory pouchitis (CARP) is a complex and often debilitating complication following ileal pouch-anal anastomosis (IPAA). Vedolizumab (VDZ), a gut-selective anti-integrin agent, has shown potential efficacy in this contex…
IntroductionB-cell malignancies, including chronic lymphocytic leukemia (CLL), pose a significant clinical challenge due to high relapse rates and dose-limiting toxicities seen with current therapies, particularly in elderly patients. Receptor tyrosine…
PurposePatients with cancer cachexia display a general resistance to immune checkpoint inhibitor (ICI) therapy, and baseline ICI catabolic clearance is a predictive indicator for overall survival, independent of dose and drug exposure. Fc-gamma (FcγRs)…
IntroductionAcute lung injury (ALI), characterized by excessive inflammation and cell death, is closely associated with ZBP1-mediated PANoptosis, a programmed cell death mechanism. The intrinsic regulatory mechanism of PANoptosis remains poorly investi…
BackgroundHead and neck squamous cell carcinoma (HNSCC) is the most common type of tumor originating from the squamous epithelium of the oral cavity, oropharynx, larynx and hypopharynx. There is an urgent need to enhance therapeutic efficacy and ensure…
T cell immunoglobulin and mucin domain-containing protein 3 (Tim-3) is an inhibitory receptor expressed on immune cells, and its co-expression with programmed cell death protein 1 (PD-1) is an established mechanism of immune exhaustion and resistance t…
