BackgroundRenal tubulointerstitial fibrosis is a reliable predictor of progressive chronic kidney disease (CKD). Activating transcription factor 4 (ATF4) has recently emerged as a pivotal player in multiple pathophysiologic processes, particularly the …
BackgroundsOvarian cancer represents a deadly gynecological malignancy, with surgical treatment being a key component of its management. We sought to integrate clinical characteristics and ascites immune microenvironment features into a deep learning m…
Dendritic cells (DCs) are crucial in regulating immune responses, making them a compelling target for immunotherapy. While DC vaccines have demonstrated safety and feasibility, their limited clinical efficacy underscores the need for strategies to enha…
BackgroundDiffuse large B cell lymphoma (DLBCL) is a highly heterogeneous lymphoid neoplasm characterized by diverse gene expression profiles and genetic alterations, resulting in substantial variations in clinical features and response to therapy. The…
IntroductionA global outbreak of Mycoplasma pneumoniae pneumonia (MPP) emerged following the Corona Virus Disease 2019 (COVID-19) pandemic. Different altitudes significantly impact community-acquired pneumonia (CAP). Whether there are differences in th…
IntroductionChronic inflammatory processes are characterized by the infiltration of chemokine-activated leukocytes into inflamed tissues. Chemokines interact with their respective G protein-coupled receptors (GPCR) on target immune cells as well as wit…
IntroductionPodocytes are essential for maintaining the structural and functional integrity of the glomerular filtration barrier. Their damage constitutes a common pathological basis for proteinuria and renal function deterioration in kidney diseases. …
IntroductionSarcoidosis is a multisystem chronic inflammatory disorder of unknown etiology that primarily affects the lungs and currently has no cure. Macrophages are central to granuloma formation, and βc cytokines tightly regulate their activation an…
BackgroundJuvenile Idiopathic Arthritis (JIA) is the most common chronic arthritis in children, causing significant joint inflammation and complications. This study evaluates the incidence, prevalence, and treatment patterns of JIA in Taiwan, focusing …
IntroductionInflammatory bowel disease (IBD) is a chronic inflammatory condition of the intestine, for which no cure currently exists. The gut microbiota play a critical role in ameliorating IBD, and Eubacterium limosum has emerged as a potential probi…
