BackgroundBladder cancer (BLCA) is among the most common malignancies worldwide, with significant mortality rates. The function of PANoptosis in BLCA, as a controlled process of programmed cell death, remains largely unelucidated. The study aimed to el…
BackgroundDuctopenia drives biochemical failure and histological progression in primary biliary cholangitis (PBC), influencing its course and prognosis, but its prevalence, features, and prognosis remain unclear. This study aimed to characterize ductop…
IntroductionLung adenocarcinoma (LUAD) is a major subtype of lung cancer with poor prognosis. The protein phosphatase 2 regulatory subunit A alpha (PPP2R1A) plays complex roles in tumorigenesis, but its function and clinical significance in LUAD remain…
IntroductionCancer survivors display impaired quality of life and increased risk to develop cardiometabolic comorbidities. Low-grade chronic inflammation (LGCI) plays a crucial role in cancer progression and in cardiometabolic diseases. Although the Me…
IntroductionChemotherapy remains the mainstay treatment for gallbladder cancer; however, its therapeutic efficacy is limited by poor chemosensitivity. Therefore, identifying more effective treatment strategies is essential for improving patient prognos…
BackgroundClinical studies have established an association between infections and circulating vitamin levels. However, the relationship stratified by specific pathogen types remains underexplored. More importantly, the causal direction of this associat…
Peyer’s patches (PPs) are lymphoid organs in the small intestine that serve as inductive sites for both humoral and cellular immune responses against the microbiota, food antigens and pathogens. PPs in germ-free mice are small and hypocellular, highlig…
IntroductionStaphylococcus aureus is the leading cause of bacterial skin infections in several inflammatory skin diseases, however, is rarely detected on healthy skin. Skin barrier defects, such as in atopic dermatitis, promote S. aureus colonization b…
Preeclampsia (PE) is a pregnancy-specific disorder marked by systemic immune imbalance and placental dysfunction, yet the link between peripheral molecular changes and tissue-level immune alterations remains incompletely understood. In this study, we i…
BackgroundSevere burn injuries can cause long-term cognitive impairments, potentially driven by lipid-mediated neuroinflammation in the central nervous system (CNS). The disruption of lipid homeostasis may contribute to neuroinflammatory responses, exa…
