BackgroundKikuchi-Fujimoto disease, also known as histiocytic necrotizing lymphadenitis (HNL), is typically self-limited but may be complicated by hemophagocytic lymphohistiocytosis (HLH) and may coexist with autoimmune disease, particularly systemic l…
BackgroundBenzene is a widespread volatile organic compound, but its effects on fetal neuroimmune development remain poorly defined. We tested whether continuous gestational benzene exposure alters fetal placenta–brain signaling, fetal brain myeloid ph…
BackgroundWhether a TREM2-high myeloid state and myeloid continuum polarization are associated with long-term cognitive survivorship in diffuse glioma has not been integrated with white matter connectomics and systemic neuroinflammation in a longitudin…
BackgroundRefractory autoimmune encephalitis (AE) is a severe condition with limited real-world evidence on treatment outcomes and prognostic factors. This study evaluated clinical outcomes and factors associated with 6-month functional recovery in a s…
BackgroundImmunogenic cell death (ICD) and tertiary lymphoid structures (TLSs) are biologically distinct yet interconnected components of antitumor immunity. ICD promotes danger-associated immune activation, whereas TLSs organize local adaptive immune …
Pathological platelet activation drives thrombosis and is a major contributor to morbidity and mortality. Current antiplatelet therapies reduce thrombotic risk but target a limited range of signaling pathways, have minimal impact on established platele…
BackgroundDermatomyositis (DM) is associated with a substantially elevated risk of malignancy, yet the cutaneous features predictive of cancer risk in adults remain insufficiently defined.ObjectivesThis study aimed to characterize cutaneous manifestati…
BackgroundGerminal centers (GCs) typically arise within the lymph node cortex, where follicular dendritic cell (FDC) networks and follicular helper T cells coordinate B-cell expansion, affinity maturation, and durable immunity. Whether proliferating B-…
IntroductionPsoriatic arthritis (PsA) and rheumatoid arthritis (RA) are chronic, inflammatory joint diseases, causing progressive structural damage. Non-immune cells, such as stromal fibroblasts promote inflammation, cartilage degradation and bone reso…
BackgroundThe present study aimed to evaluate the acute toxicity of endosulfan (99% purity; α:β ratio of 7:3) in milkfish (Chanos chanos) under freshwater acclimated conditions over a 96-hour exposure period. Milkfish (C. chanos) is a commercially impo…
