Association between systemic immune-inflammation index and central obesity in pediatric populations: a cross-sectional and cohort study

BackgroundCentral obesity in children represents a significant public health concern due to its strong association with an elevated risk of metabolic and cardiovascular disorders. The systemic immune inflammation index (SII) has been implicated in the …

Tacrolimus (FK506) promotes placentation and maternal-fetal tolerance through modulating FASN-CEACAM1 pathway

The establishment of placentation and maternal-fetal tolerance are important determinants of a successful pregnancy. Tacrolimus, also known as FK506, is a calcineurin inhibitor that has often been used for pregnant women after solid organ transplantati…

Systemic inflammation is an important risk factor and predictor of graft loss and mortality one year after kidney transplantation

BackgroundAn inflammatory environment following kidney transplantation is associated with increased risk of graft loss and mortality, however, evaluation of systemic inflammation is not implemented in structured risk assessment in kidney transplant rec…

Aberrant lipid profiles and lymphocyte counts in systemic sclerosis population, reassessing predictive value for concurrent cardiovascular diseases

ObjectiveTo investigate alterations in blood lipid profiles and T cell subsets among systemic sclerosis (SSc) patients, and to assess their potential utility in predicting cardiovascular disease (CVD) risk.Methods105 SSc patients and 80 age- and sex-ma…

Cytokine profiles and CD4 counts in HIV-positive individuals with cysticercosis: implications for sex-specific immune responses in co-endemic regions of Tanzania

IntroductionThe interplay between HIV and Taenia solium cysticercosis in co-endemic regions remains poorly understood, particularly regarding the immune responses but is relevant for an effective treatment strategy. This study aimed to investigate the …

Chronic hypoxia has differential effects on constitutive and antigen-stimulated immune function in Atlantic salmon (Salmo salar)

Chronic hypoxia events are a common occurrence in Atlantic salmon (Salmo salar) sea-cages, especially during the summer, and their frequency and severity are predicted to increase with climate change. Although hypoxia is considered a very important fis…

A novel glycolysis-related gene signature for predicting prognosis and immunotherapy efficacy in breast cancer

BackgroundPrevious studies have shown that glycolysis-related genes (GRGs) are associated with the development of breast cancer (BC), and the prognostic significance of GRGs in BC has been reported. Considering the heterogeneity of BC patients, which m…

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