Cancer Immunology Reserch

Pan-cancer single-cell RNA sequencing analysis refines multi-origin monocyte and macrophage lineages

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Cancer Immunol Res. 2025 Nov 13. doi: 10.1158/2326-6066.CIR-24-1255. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) play crucial and important role in cancer dynamics by affecting homeostasis, immunosuppression, and angiogenesis within the tumor microenvironment. Using single-cell transcriptomics, we constructed a comprehensive atlas of myeloid cell populations across healthy and pan-cancer tissues that revealed heterogeneity. Our … Read more

T-cell Subset Features and Distributions Evolve Across the Colorectal Precancer-Cancer Spectrum

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Cancer Immunol Res. 2025 Nov 12. doi: 10.1158/2326-6066.CIR-25-0481. Online ahead of print. ABSTRACT The immune microenvironment is a crucial component of colorectal carcinoma (CRC) that has been well characterized, but much less is known about the immune microenvironment of CRC precursors. We hypothesized that T-cell infiltrates might differ across the colorectal neoplastic spectrum. We leveraged … Read more

FAM135B Deficiency Inhibits Cytotoxic T-Cell Activity in Triple-negative Breast Cancer by Blocking the IFI16-dependent STING Pathway

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Cancer Immunol Res. 2025 Nov 11. doi: 10.1158/2326-6066.CIR-25-0310. Online ahead of print. ABSTRACT Despite advances in immune checkpoint blockade (ICB) for cancer treatment, only a minority of triple-negative breast cancer (TNBC) patients derive benefits, and the underlying mechanisms remain largely unknown. Herein, sequence similarity 135 family member B (FAM135B) is identified as a regulator of … Read more

Intratumoral three-cell-type clusters are a conserved feature of endogenous antitumor immunity

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Cancer Immunol Res. 2025 Nov 7. doi: 10.1158/2326-6066.CIR-25-0062. Online ahead of print. ABSTRACT Effective antitumor immunity ultimately depends on the priming and activation of tumor-specific cytotoxic CD8+ T cells; however, the role of intratumoral cell-cell immune interactions remains incompletely understood. Recent work has revealed that the temporospatial colocalization of dendritic cells (DCs), helper T cells … Read more

TIME for Endometrial Cancer: Advancements and Challenges in Therapeutic Targets for the Endometrial Cancer Tumor Immune Microenvironment

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Cancer Immunol Res. 2025 Nov 7:OF1-OF17. doi: 10.1158/2326-6066.CIR-25-0438. Online ahead of print. ABSTRACT Endometrial cancer is the sixth most common cancer in women worldwide and the fourth most common cancer in women in the United States. In the United States, its incidence and mortality rates have continued to increase since the late 1990s. Endometrial cancer … Read more

RAS(ON) multi-selective inhibition drives antitumor immunity in preclinical models of NRAS-mutant melanoma

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Cancer Immunol Res. 2025 Nov 4. doi: 10.1158/2326-6066.CIR-25-0744. Online ahead of print. ABSTRACT Targeted therapies for NRAS-mutant melanoma remain an unmet clinical need. Here, we demonstrate that RMC-7977, a preclinical RAS(ON) multi-selective inhibitor representative of the investigational agent daraxonrasib (RMC-6236), was able to elicit potent antitumor immune responses across multiple NRAS-mutant melanoma models. Treatment with … Read more

IL4/IL13 inhibition via dupilumab reduces malignant T cell proliferation and promotes antitumor immunity in Sezary syndrome

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Cancer Immunol Res. 2025 Oct 29. doi: 10.1158/2326-6066.CIR-25-0677. Online ahead of print. ABSTRACT Patients with Sezary syndrome (SS), the aggressive leukemic variant of cutaneous T cell lymphoma (CTCL), have few therapeutic options and a poor prognosis. We previously showed that the IL4/IL13 signaling pathway impacts SS tumorigenesis. Here, we investigated the potential therapeutic effect of … Read more

Downregulation of HLA Class I Expression Through HLA-A DNA Methylation Is Associated with Reduced CD8+ T Cell Infiltration in Cervical Cancer

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Cancer Immunol Res. 2025 Oct 27. doi: 10.1158/2326-6066.CIR-25-0594. Online ahead of print. ABSTRACT Human leukocyte antigen class I (HLA-I) is central to tumor immune recognition, but its regulatory mechanisms in cervical cancer remain poorly understood. This study aimed to elucidate the impact of HLA-I regulatory mechanisms on CD8+ T cell infiltration and identify distinct histotype-specific … Read more

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