Curr Opin Immunol. 2024 Oct 25;91:102498. doi: 10.1016/j.coi.2024.102498. Online ahead of print. ABSTRACT Aging is one of the greatest risk factors for several chronic diseases and is accompanied by a progressive decline of cellular and organ function. Recent studies have highlighted the changes in metabolism as one of the main drivers of organism dysfunctions during … Read more
Curr Opin Immunol. 2024 Oct 8;91:102472. doi: 10.1016/j.coi.2024.102472. Online ahead of print. ABSTRACT Successful treatment of infectious diseases requires a multiprong approach involving strategies that limit pathogen burdens and that limit disease. Traditionally, disease defense is thought to be a direct function of pathogen killing, and thus, our current methods for treating infections have largely … Read more
Curr Opin Immunol. 2024 Oct 4;91:102491. doi: 10.1016/j.coi.2024.102491. Online ahead of print. ABSTRACT Tumor-associated macrophages (TAMs) constitute the primary subset of immune cells within the tumor microenvironment (TME). Exhibiting both phenotypic and functional heterogeneity, TAMs play distinct roles in tumor initiation, progression, and responses to therapy in patients with cancer. In response to various immune … Read more
Curr Opin Immunol. 2024 Oct 3;91:102497. doi: 10.1016/j.coi.2024.102497. Online ahead of print. ABSTRACT Neutrophils, the first responders of the innate immune system, can turn on a range of effector functions upon activation. Emerging research shows activated neutrophils undergo highly dynamic metabolic rewiring. This metabolic rewiring provides energy and reducing power to fuel effector functions and … Read more
Curr Opin Immunol. 2024 Sep 30;91:102482. doi: 10.1016/j.coi.2024.102482. Online ahead of print. ABSTRACT Five mammalian Toll-like receptors (TLR 3, 7, 8, 9, and 13) recognize nucleic acids (NA) and induce signals that control the function of multiple immune cell types and initiate both innate and adaptive immune responses. While these receptors enable recognition of diverse … Read more
Curr Opin Immunol. 2024 Sep 30;91:102486. doi: 10.1016/j.coi.2024.102486. Online ahead of print. ABSTRACT Emerging studies on the diet-immune axis have uncovered novel dietary immune regulators and identified crucial targets and pathways mediating the crosstalk between specific dietary components and diverse immune cell populations. Here, we discuss the recent discovery and mechanisms by which diet-derived components, … Read more
Curr Opin Immunol. 2024 Oct 1;91:102483. doi: 10.1016/j.coi.2024.102483. Online ahead of print. ABSTRACT T helper 2 (TH2) cells orchestrate type 2 immunity during protective antihelminth immunity and help restore tissue homoeostasis. Their misdirected activities against innocuous substances also underlie atopic diseases, such as asthma and allergy. Recent technological advances are uncovering novel insights into the … Read more
Curr Opin Immunol. 2024 Oct 1;91:102495. doi: 10.1016/j.coi.2024.102495. Online ahead of print. ABSTRACT Intricate immune regulation is required at mucosal surfaces to allow tolerance to microbiota and harmless allergens and to prevent overexuberant inflammatory responses to pathogens. The cytokine Interleukin-10 (IL-10) is a key mediator of mucosal immune regulation. While IL-10 can be produced by … Read more
Curr Opin Immunol. 2024 Oct 1;91:102485. doi: 10.1016/j.coi.2024.102485. Online ahead of print. ABSTRACT Aging, metabolism, and immunity have long been considered distinct domains. Aging is primarily associated with the gradual decline of physiological functions, metabolism regulates energy production and maintains cellular processes, and the immune system manages innate and adaptive responses against pathogens and vaccines. … Read more
Curr Opin Immunol. 2024 Oct 1;91:102484. doi: 10.1016/j.coi.2024.102484. Online ahead of print. ABSTRACT B cells experience extreme alterations in their metabolism throughout their life cycle, from naïve B cells, which have minimal activity, to germinal centre (GC) B cells, which proliferate at the fastest rate of all cells, to long-lived plasma cells with very high … Read more
