Epithelial sensing in allergic disease

Curr Opin Immunol. 2024 Sep 25;91:102490. doi: 10.1016/j.coi.2024.102490. Online ahead of print. ABSTRACT Epithelial cells provide a first line of immune defense by maintaining barrier function, orchestrating mucociliary clearance, secreting antimicrobial molecules, and generating sentinel signals to both activate innate immune cells and shape adaptive immunity. Although epithelial alarmins play a particularly important role in … Read more

Multilevel approaches to immunization equity

Curr Opin Immunol. 2024 Sep 24;91:102496. doi: 10.1016/j.coi.2024.102496. Online ahead of print. ABSTRACT Over the last 2 years, immunization disparities have surged due to a pandemic, violent conflicts, economic crises, and their disrupting effects on health care systems. This review provides a multilevel framework for understanding vaccination disparities and provides examples of work addressing disparities … Read more

The role of intestinal bacteria in promoting tolerance to food

Curr Opin Immunol. 2024 Sep 25;91:102492. doi: 10.1016/j.coi.2024.102492. Online ahead of print. ABSTRACT The global prevalence of atopic diseases, including food allergy, is increasing and correlates with shifts in the commensal microbiota triggered by modern lifestyle factors. Current research focuses on the immunological mechanisms and microbial cues that regulate mucosal immunity and prevent allergic responses … Read more

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