Current Opinion in Immunology

Curr Opin Immunol. 2026 Feb 27;99:102742. doi: 10.1016/j.coi.2026.102742. Online ahead of print. ABSTRACT Rheumatoid arthritis (RA) is a highly heterogeneous chronic systemic inflammatory disease. Approximately 30-40% of patients exhibit an inadequate response to currently available biologic agents and Janus kinase inhibitors. In recent years, rapid advances in multi-omics technologies, including genomics, temporal transcriptomics, proteomics, metabolomics, … Read more

Curr Opin Immunol. 2026 Feb 27;99:102746. doi: 10.1016/j.coi.2026.102746. Online ahead of print. ABSTRACT PURPOSE OF REVIEW: Psoriatic arthritis (PsA) is a multidomain inflammatory disease where no instrument captures the full spectrum of activity or its impact on patients’ lives. Accurate outcome measurement is essential for research and personalized care. This review summarizes advances in PsA … Read more

Curr Opin Immunol. 2026 Feb 18;99:102741. doi: 10.1016/j.coi.2026.102741. Online ahead of print. ABSTRACT Outcomes in Sjögren disease (SjD) have ranged from diverse symptom scales to the validated EULAR Sjögren’s Syndrome Patient Reported Index (ESSPRI) and EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI), which now provide a common framework for evaluating symptoms and systemic activity. In … Read more

Curr Opin Immunol. 2026 Feb 17;99:102738. doi: 10.1016/j.coi.2026.102738. Online ahead of print. ABSTRACT Antimicrobial peptides and proteins (AMPs) function as molecular rheostats of host-microbe interactions and cell-intrinsic defense. Rather than being binary effectors, they act along a continuum. At basal levels, AMPs maintain harmony with the commensal members of the microbiome, and upon pathogen encounter, … Read more

Curr Opin Immunol. 2026 Feb 16;99:102739. doi: 10.1016/j.coi.2026.102739. Online ahead of print. ABSTRACT Sjögren’s disease (SjD) is a chronic, systemic autoimmune disease that mainly targets saliva- and tear-producing glands. T-cells are a substantial immune cell subset involved in SjD pathogenesis, including break of tolerance toward self, and constitute a major part of tissue-resident and infiltrating … Read more

Curr Opin Immunol. 2026 Feb 14;99:102736. doi: 10.1016/j.coi.2026.102736. Online ahead of print. ABSTRACT Multiple sclerosis (MS) is traditionally considered a chronic immune-mediated disease of the central nervous system. However, increasing evidence suggests substantial clinical, radiological, and immunopathological heterogeneity among individuals diagnosed with MS. In recent years, increasing awareness of this heterogeneity has led to a … Read more

Curr Opin Immunol. 2026 Feb 13;99:102734. doi: 10.1016/j.coi.2026.102734. Online ahead of print. ABSTRACT The cation channel and protein kinase transient receptor potential cation channel subfamily M member 7 (TRPM7) has been linked to immune homeostasis, immune cell signaling and differentiation, and inflammatory diseases. Its importance in guiding ion-mediated cellular responses, funneling discrete kinase signal transduction … Read more

Curr Opin Immunol. 2026 Feb 13;99:102737. doi: 10.1016/j.coi.2026.102737. Online ahead of print. ABSTRACT Minor salivary gland biopsy occupies a distinctive position in the evaluation of Sjögren disease (SjD), offering diagnostic and prognostic insights that are rarely achievable in other systemic autoimmune conditions. It contributes essential diagnostic information, particularly for patients lacking anti-Ro/SSA antibodies or pediatric … Read more

Curr Opin Immunol. 2026 Feb 13;99:102740. doi: 10.1016/j.coi.2026.102740. Online ahead of print. ABSTRACT Regulated cell death, including apoptosis, necroptosis, and pyroptosis, as well as cell death arising from disrupted cellular homeostasis, such as ferroptosis and dysregulated autophagy, is implicated in cancer, autoimmunity, and transplantation biology. Graft-versus-host disease (GVHD), a major cause of morbidity and mortality … Read more

Curr Opin Immunol. 2026 Feb 11;99:102735. doi: 10.1016/j.coi.2026.102735. Online ahead of print. ABSTRACT The clinical heterogeneity of rheumatoid arthritis (RA) reflects a series of dynamic immunological imbalances rather than a single dominant mechanism. In this review, we propose that RA progression is best understood as a sequence of three functional balances. The first contrasts pathogenic … Read more