European Journal of Immunology

Neuro‐ILC Interactions in Host Physiology and Defence. [[{“value”:”Cristina Godinho‐Silva, Miguel Rendas, Henrique Veiga‐Fernandes”}]]

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Local and systemic neuroimmune interactions involving innate lymphoid cells (ILCs) shape organismal physiology and defence. Neuro-ILC circuits operate across different organs through brain–body and inter-organ communication axes. These neuroimmune circuits integrate external environmental cues and internal physiological signals to regulate organ physiology, thermogenesis, metabolism, endocrine function, and organismal health. ABSTRACT Over the past decade, innate … Read more

HLA‐DR‐Expressing γδ T Cells Facilitate the Anti‐Leukemia Activity of αβ T Cells. [[{“value”:”Keli Yue, Shuang Liang, Ning Wu, Mingzhu Jia, Haitao Gao, Cong Cheng, Lijuan Hu, Jiangying Liu”}]]

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• Dysregulated HLA-DR expression on γδ T cells and impaired functionality of αβ T cells were found in the bone marrows of AML patients. • The ex vivo-expanded donor γδ T cells with high expression of HLA-DR facilitated the cytotoxic effect of αβ T cells. ABSTRACT In addition to exhibiting significant cytotoxic capabilities, γδ T … Read more

Granulysin Antimicrobial Activity Promotes Dormancy in Mycobacterium tuberculosis. [[{“value”:”Sarah Schmidiger, Erin F. McCaffrey, Jan M. Schmidt, Owais Abdul Hameed, Max Mpina, Anneth Tumbo, Elirehema Mfinanga, Frederick Haraka, Hellen Hiza, Mohamed Sasamalo, Jerry Hella, Michael Walch, Jacques Fellay, Sébastien Gagneux, Klaus Reither, José M. Carballido, Ainhoa Arbués, Damien Portevin”}]]

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Exploiting a high-dimensional mass cytometry approach, we demonstrate that CD56+ lymphocytes promote Mycobacterium tuberculosis dormancy by delivering granulysin, a cytotoxic effector molecule with known antimicrobial activity. ABSTRACT Human tuberculosis (TB) caused by Mycobacterium tuberculosis (Mtb) remains a global public health threat. Granulomas constitute a hallmark of TB pathogenesis that can clear, contain, or exacerbate an … Read more

Suppressor of Cytokine Signaling Mimetics as a Therapeutic Approach in Autoimmune Encephalitis. [[{“value”:”Rahul Pandey, Marina Bakay, Hakon Hakonarson”}]]

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SOCS mimetics target dysregulated cytokine signaling, offering promising immunomodulatory therapy for autoimmune encephalitis by suppressing cytokine signaling, reducing neuroinflammation, and preserving blood–brain barrier integrity. ABSTRACT Autoimmune encephalitis (AE) is a debilitating neurological condition characterized by the immune system’s attack on neuronal cells, often leading to significant cognitive and neurological impairments. Autoantibodies, particularly those targeting N-methyl-D-aspartate … Read more

Exploring How Cytoskeleton Dynamics Tunes T Cell Activation at the Immunological Synapse. [[{“value”:”Álvaro Gómez‐Morón, Adrián González‐Pinar, Carlos Carrasco‐Padilla, Pedro Roda‐Navarro, Noa Beatriz Martín‐Cófreces”}]]

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T cell receptor engagement induces coordinated actin and microtubule cytoskeletal remodeling at the immunological synapse. This dynamic reorganization generates mechanical forces that sustain TCR signaling and promote effective T cell activation. The SSH1–cofilin–LIMK1 signaling pathway plays a pivotal role in regulating cytoskeletal dynamics during this process. ABSTRACT During T cell immune responses, actin dynamics facilitates … Read more

Generation of Regulatory T Cells From Human Memory CD4+T Cells by Upregulation of Naked Cuticle Homolog 2. [[{“value”:”Jiajun He, Kristy Ou, Michael Schmueck‐Henneresse, Edgar Specker, Jérôme Paul, Marc Nazare, Jens Peter von Kries, Julia K. Polansky, Alf Hamann, Stefan Frischbutter”}]]

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This study discovered the small molecule 9-methoxy-6-methylindolo[3,2-b] quinoxaline (IFA005) as a potent immunomodulator capable of converting human memory CD4⁺ T cells into functional Foxp3⁺ regulatory T cells. IFA005 suppresses Th2 cytokines (IL-4, IL-5, and IL-13) and promotes the iTreg phenotype by inhibiting Wnt/β-catenin signaling through NKD2 upregulation. These findings support small-molecule-mediated Wnt/β-catenin blockade as a … Read more

Current and Emerging Autoantibodies in Ulcerative Colitis. [[{“value”:”Erick A. Mendieta‐Escalante, Klaas Nico Faber, Gerard Dijkstra”}]]

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Autoantibodies in ulcerative colitis target neutrophil and mucosal components, including NETs, goblet cells, and integrins-offering insight into disease pathophysiology. Understanding these interactions may support biomarker development, enable earlier diagnosis, aid patient stratification, and drive future therapeutic innovation. ABSTRACT Ulcerative colitis (UC) is a chronic inflammatory bowel disease characterized by immune dysregulation and epithelial barrier dysfunction. … Read more

Neutrophil Heterogeneity Identifies an Association of LAMP1 With Proliferative Lupus Nephritis. [[{“value”:”Lennard Ostendorf, Panagiotis Garantziotis, Frank Y. Huang, Georg Schett, Accelerating Medicines Partnership: RA/SLE Network, James A. Lederer, Andrea Fava, Deepak A. Rao, Ricardo Grieshaber‐Bouyer”}]]

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We investigated neutrophil heterogeneity in patients with systemic lupus erythematosus and identified increased surface levels of LAMP1 (CD107a). Stimulation of healthy donor neutrophils led to increased surface LAMP1. Urine and serum soluble LAMP1 levels were increased in patients, especially those with proliferative lupus nephritis. ABSTRACT Lupus nephritis (LN) is a severe manifestation of systemic lupus … Read more

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