European Journal of Immunology

Exosome miR‐6990‐5p from MMP14high Macrophage Promotes Fibrosis Through Th17 Cell Differentiation in Hypersensitivity Pneumonia. [[{“value”:”Dan Peng, Juan Li, Bomiao Qin, Anying Xiong, Qin Ran, Lingling Bai, Xiang He, Xiaolan Li, Lei Zhang, Madeeha Arooj, Guoping Li”}]]

by

miR-6990 5p, derived from exosomes of MMP14high macrophages, promotes Th17 cell differentiation through the STAT1/RUNX1/ROR-γt signaling axis and enhances IL-17A secretion. This cascade facilitates fibroblast-to-myofibroblast transition and aggravates fibrosis in hypersensitivity pneumonitis. ABSTRACT Th17 cells contribute to pulmonary fibrosis, but the mechanisms driving their differentiation remain unclear. Using single-cell RNA sequencing (scRNA-seq) and a decision … Read more

Significance of miRNA Profile of Regulatory T Cells (Tregs) After Baricitinib Treatment in Rheumatoid Arthritis Patients. [[{“value”:”Magdalena Massalska, Anna Felis‐Giemza, Patrycja Gardias, Tomasz Burakowski, Anna Kornatka, Paulina Klimek, Magdalena Plebanczyk, Marta Marecka‐Kuzdub, Weronika Kurowska, Ewa Kuca‐Warnawin, Wlodzimierz Maslinski, Marzena Ciechomska”}]]

by

We analyzed the expression levels of miRNAs in Treg cells and thrombotic parameters in plasma of patients with rheumatoid arthritis (RA) before and after baricitinib (BARI) treatment. Four miRNAs were identified that showed a positive correlation with thrombotic parameters and were associated with an improved therapeutic response to BARI. ABSTRACT Several studies proved that microRNA … Read more

Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells. [[{“value”:”Kevin Schmid, Robin P. Schenk, Gabriela M. Wiedemann”}]]

by

Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

TNF Production or TNFR2 Expression Characterize Distinct States of Regulatory T Cells that Cooperate in Treg Expansion in Cancer and Chronic Inflammation. [[{“value”:”Gloria Tucci, Ilenia Pacella, Alessandra Pinzon Grimaldos, Alessandra Rossi, Ilenia Cammarata, Marta Zagaglioni, Giovanna Peruzzi, Valentina Tirelli, Massimo Sanchez, Giuseppe Pietropaolo, Francesca Sozio, Annalisa Del Prete, Valerio Licursi, Vincenzo Barnaba, Silvia Piconese”}]]

by

Tregs exist in two functional states: TNF-producing Tregs, which are expanded in mouse models of chronic inflammation and cancer, and TNFR2-expressing Tregs, which dominate and transmit their phenotype to TNF+ Tregs. The two states are characterized by distinct phenotypic and functional features. Created in BioRender. Piconese, S. (2025) https://BioRender.com/5cldomx. ABSTRACT TNF is a pleiotropic cytokine … Read more

Partial Compensation of IL‐17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells. [[{“value”:”Ziqing Wang, Tao Yang, Federico Lupo, Lara‐Marie Behrens, Anika Janssen, Seth B. Coffelt, Immo Prinz, Inga Sandrock, Sarina Ravens”}]]

by

In the absence of Vγ4⁺ and Vγ6⁺ γδ TCRs, Vγ1 T cells only partially compensate for IL-17 production. These Vγ1 T cells develop pre- and postnatally and show enhanced γδ17 gene signature, but are absent in skin, highlighting the nonredundant role of Vγ4⁺ and Vγ6⁺ subsets in IL-17-mediated immunity. ABSTRACT γδ T cells are unconventional … Read more

Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy‐Supportive Phenotype In Vitro. [[{“value”:”Stefanie Dietz‐Ziegler, Samantha Kewitz, Gabriele Kaiser, Jessica Rühle, Alexander Marmé, Alexander Dalpke, Bachar Cheaib, Jan Pauluschke‐Fröhlich, Melanie Henes, Ana Velic, Andreas Pich, Anneli Vollert, Martin Schaller, Felix Knab, Trim Lajqi, Christian F. Poets, Christian Gille, Natascha Köstlin‐Gille”}]]

by

Fecal extracellular vesicles (fEVs) were isolated from preserved stool samples in DNA/RNA shield and characterized. In an in vitro model with PBMC, fEVs of pregnant women modulate T cells toward a regulatory phenotype favorable for pregnancy compared to fEVs of non-pregnant women. ABSTRACT Pregnancy requires immune tolerance to a semi-allogeneic fetus, involving profound adaptations, particularly … Read more

Activation of CD8⁺ T Cells in the Human Ex Vivo Lung Tumor Microenvironment Using Anti‐CD3/CD28 and Nivolumab. [[{“value”:”Tonia Bargmann, Sebastian Konzok, Renato Liguori, Maximilian Fuchs, Charline Sommer, Dirk Schaudien, Charlotte Schob, Stephan Halle, Christopher Werlein, Patrick Zardo, Lavinia Neubert, Danny Jonigk, Hans‐Gerd Fieguth, Fulvia Ferrazzi, Katherina Sewald, Susann Dehmel, Armin Braun”}]]

by

Patient heterogeneity remains a challenge in the treatment of lung cancer. Here, patient-derived, ex vivo tumor lung slices originating from the tumor-border are used to unravel microenvironment-specific responses to immunotherapies. The focus lies on the impact of the native tumor microenvironment on CD8+ T cell activation after anti-CD3/CD28 or anti-PD-1 treatment. ABSTRACT Despite advancements in … Read more

What We Know and What We Don’t Know About the Function of γδ T Cells. [[{“value”:”Immo Prinz, Anja Meyer”}]]

by

This mini-review introduces a special issue on γδ T cells in the European Journal of Immunology. It summarizes how recent advances in single-cell multiomics, mouse models, and human studies have clarified the developmental pathways, TCR–ligand interactions, and adaptive-like responses of γδ T cells. A thorough understanding of the complex biology of these cells is necessary … Read more

deneme bonusu veren siteler - canlı bahis siteleri - casino siteleri casino siteleri deneme bonusu veren siteler canlı casino siteleri