European Journal of Immunology

From Histology to High‐Resolution Mapping: The Rise of Spatial Omics in Immunology. [[{“value”:”Marco De Giovanni, Donato Inverso, Matteo Iannacone”}]]

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Immune regulation is fundamentally spatial, shaped by tissue architecture and local cues. Spatial omics—transcriptomic, proteomic, metabolomic, lipidomic, and phosphoproteomic platforms—preserve coordinates while capturing high-dimensional data, revealing region-specific programs and niches. This review surveys key methods and applications in the intestine, lymphoid organs, and liver. ABSTRACT The immune system is deeply shaped by its anatomical context, … Read more

Purin Metabolism Is Crucial for Regulatory T Cell Stability and Function. [[{“value”:”Young S. Lee, Marina W. Shirkey, Vikas Saxena, Dejun Kong, Bing Ma, Reza Abdi, Jonathan S. Bromberg”}]]

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Purine Metabolism and Treg Stability. Nuermous enzymes (colored boxes) facilitate the conversion of ATP into AMP, ADO, IMP, inosine, and hypoxanthine. Purine metabolites can be recycled through the purine salvage pathway or undergo degradation to form uric acid, or be transported to the extracellualr environment. The pertubation of purine pathways can lead to significant changes … Read more

Imaging Mass Cytometry‐Based Immune Profiling of Human Peyer’s Patches in Patients with Crohn’s Disease. [[{“value”:”Adrian Huck, Yasmina Rodriguez‐Sillke, Christian Bojarski, Désirée Kunkel, Anja A. Kühl, Malte Lehmann, Philip Bischoff, Ulrich Steinhoff, Britta Siegmund, Rainer Glauben”}]]

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Using imaging mass cytometry (IMC), we spatially profiled Peyer’s patches and lymphoid follicles in IBD. In colonic Crohn’s disease, follicles showed enriched activated CD8⁺ T cells and B–T neighbourhoods—most pronounced in small B-cell patches—whereas ileitis resembled healthy tissue. Spatial features outperformed simple cell-frequency readouts. ABSTRACT Lymphoid follicles in the human gut are critical immune hubs, … Read more

Equine Asthma Is Characterised by Severity‐Dependent Correlations Between Blood Neutrophil Cholesterol Content and NET Formation. [[{“value”:”Lia K. Meiseberg, AhmedElmontaser Mergani, Julien Delarocque, Rabea Imker, Darleen Köhn, Dalanda Wanes, Marta C. Bonilla, Edwin J. A. Veldhuizen, Maren von Köckritz‐Blickwede, Bernhard Ohnesorge, Nicole de Buhr”}]]

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Analysis of BALF and blood of asthmatic horses revealed local and systemic immunological variations related to NET formation and cholesterol homeostasis. Higher NET formation, lower cellular cholesterol and dysregulated NET regulators (e.g., eCATH, DNase, ANCAs) were associated with clinical disease severity. These results provide novel mechanistic insights into EA pathogenesis. ABSTRACT Equine asthma (EA) is … Read more

Antigen‐Specific Tolerance: Clinical and Preclinical Approaches in Autoimmunity. [[{“value”:”Priscilla P. M. Faas, Stephanie D. Scharmann, Novalia Pishesha”}]]

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Recent clinical trials highlight the potential of antigen-specific tolerance therapies in autoimmune disease. Building on this, next-generation preclinical studies explore innovative delivery systems, engineered immune cells, and biomaterials to enhance precision and durability, paving the way for future patient-tailored treatments. Created in BioRender. Faas, P. (2025) https://BioRender.com/7w78327. ABSTRACT Autoimmune diseases arise from a breakdown in … Read more

Exosome miR‐6990‐5p from MMP14high Macrophage Promotes Fibrosis Through Th17 Cell Differentiation in Hypersensitivity Pneumonia. [[{“value”:”Dan Peng, Juan Li, Bomiao Qin, Anying Xiong, Qin Ran, Lingling Bai, Xiang He, Xiaolan Li, Lei Zhang, Madeeha Arooj, Guoping Li”}]]

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miR-6990 5p, derived from exosomes of MMP14high macrophages, promotes Th17 cell differentiation through the STAT1/RUNX1/ROR-γt signaling axis and enhances IL-17A secretion. This cascade facilitates fibroblast-to-myofibroblast transition and aggravates fibrosis in hypersensitivity pneumonitis. ABSTRACT Th17 cells contribute to pulmonary fibrosis, but the mechanisms driving their differentiation remain unclear. Using single-cell RNA sequencing (scRNA-seq) and a decision … Read more

Significance of miRNA Profile of Regulatory T Cells (Tregs) After Baricitinib Treatment in Rheumatoid Arthritis Patients. [[{“value”:”Magdalena Massalska, Anna Felis‐Giemza, Patrycja Gardias, Tomasz Burakowski, Anna Kornatka, Paulina Klimek, Magdalena Plebanczyk, Marta Marecka‐Kuzdub, Weronika Kurowska, Ewa Kuca‐Warnawin, Wlodzimierz Maslinski, Marzena Ciechomska”}]]

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We analyzed the expression levels of miRNAs in Treg cells and thrombotic parameters in plasma of patients with rheumatoid arthritis (RA) before and after baricitinib (BARI) treatment. Four miRNAs were identified that showed a positive correlation with thrombotic parameters and were associated with an improved therapeutic response to BARI. ABSTRACT Several studies proved that microRNA … Read more

Low‐Input Assay for Transposase‐Accessible Chromatin Identifies Epigenetic Signatures of Liver Group 1 Innate Lymphoid Cells. [[{“value”:”Kevin Schmid, Robin P. Schenk, Gabriela M. Wiedemann”}]]

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Assessing chromatin accessibility in rare cell populations within tissue remains a key challenge. To address this, we present a low-input ATAC workflow optimized for liver ILCs. The protocol is validated across cell numbers, Tn5 ratios, and library preparation steps and unveils unique epigenetic features of liver NK cells and ILC1s.

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