European Journal of Immunology

Atg16l2 augments Nlrc4 inflammasome activation by facilitating NAIPs–NLRC4 association. [[{“value”:”Zhoujin Wen, Tianli Yuan, Jiamin Liu, Dongyang Wang, Jun Ni, Xuehan Yan, Jian Tang, Jiayin Tang, Xuefeng Wu, Zheng Wang”}]]

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Schematic diagram of ATG16L2-mediated NLRC4 inflammasome activation during Salmonella typhimurium infection. After NAIPs recognize the different components of S. typhimurium, ATG16L2 promotes the binding of NAIPs to NLRC4, enhancing the oligomerisation of ASC and the subsequent caspase-induced cleavage of IL-1β and GSDMD. N-terminal perforates the cell membrane, causing pyroptosis and LDH leakage. Abstract As cytoplasmic … Read more

Molecular and functional in vivo characterisation of murine Dectin‐1 isoforms. [[{“value”:”Nadja Leinung, Torben Mentrup, Sajma Hodzic, Bernd Schröder”}]]

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Dectin-1 is a C-type lectin receptor for the innate sensing of fungi. This receptor exists in two major isoforms in mice differing in a stalk domain, which determines their degradative pathway. Here, we characterise the properties of the two isoforms in a cellular context and using a newly established in vivo model. Abstract Dectin-1 is … Read more

Modulation of the K/BxN arthritis mouse model and the effector functions of human fibroblast‐like synoviocytes by liver X receptors. [[{“value”:”María Jesús Domínguez‐Luis, Javier Castro‐Hernández, Sergio Santos‐Concepción, Ana Díaz‐Martín, Mayte Arce‐Franco, Natán Pérez‐González, Mercedes Díaz, Antonio Castrillo, Eduardo Salido, José David Machado, Mónica Gumá, Maripat Corr, Federico Díaz‐González”}]]

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In the K/BxN arthritis mouse model, Nr1h2/3−/− animals showed exacerbated arthritis, histologic inflammation and joint destruction, and increased synovial metalloproteases, IL-1β and CCL2 in joints compared with wild-type animals. In FLS from RA patients, LXR agonists inhibited cell proliferation and collagenase activity in response to TNF, chemokine-induced migration, and CXCL12 production. Abstract The role of … Read more

Alveolar epithelial cells shape lipopolysaccharide‐induced inflammatory responses and reprogramming of alveolar macrophages. [[{“value”:”Wei Jiang, Yeying Chen, Cheng‐Yun Yu, Benkun Zou, Yimeng Lu, Qian Yang, Zihui Tang, Weiying Mao, Jing Li, Han Han, Lingyun Shao, Jiashun Zeng, Yiwei Chu, Jianguo Tang, Mingfang Lu”}]]

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After exposure to LPS, Alveolar macrophages (AMs) secrete TNF-α to induce GM-CSF production by alveolar epithelial cells (AECs). GM-CSF promotes AMs to secrete IL-6 and primes AMs for subsequent challenges. These results show that in response to MAMP stimulation, AMs and AECs respond collaboratively and AMs are primed. Abstract Alveolar macrophages (AMs) are sentinels in … Read more

Immune response to topical sodium lauryl sulfate differs from classical irritant and allergic contact dermatitis. [[{“value”:”Marvin Nüsken, Fabian Heinemeier, Silke Sabina Matzke, Patryk Porebski, Susann Forkel, Prasad Dasari, Andrea Braun, Andreas Erich Zautner, Michael Peter Schön, Timo Buhl”}]]

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We investigated sodium lauryl sulfate (SLS)-skin reactions because of its relevance in patch tests of patients, and we compared its effects with ACD-inducing oxazolone (OXA) and ICD-inducing croton oil (CrO). SLS-induced contact dermatitis differed from classical ACD and ICD, as it elicited less pronounced immune alterations. Abstract Sodium lauryl sulfate (SLS) is used as a … Read more

The macrophage migration inhibitory factor/CD74 axis in traumatic spinal cord injury: lessons learned from animal and human studies. [[{“value”:”Serina Rubio, Veerle Somers, Judith Fraussen”}]]

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Both animal and human studies have indicated the importance of MIF and CD74 in traumatic SCI. This review discusses how the MIF/CD74 axis affects numerous cell types and recovery post-SCI and proposes a new path for investigation focused on B cells. Abstract Traumatic spinal cord injury (SCI) is a severe condition leading to long-term impairment … Read more

Characterizing dynamic tumor–immune interactions in lung adenocarcinoma through orthotopic allograft modeling. [[{“value”:”Mingjun Shi, Tianqi Dong, Jiaming Lin, Liu Huang, Huixia Zhang, Shuguo Sun”}]]

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An orthotopic lung adenocarcinoma allograft model with fluorescently labeled cells was developed to investigate the tumor microenvironment. Results demonstrate that CCL7 promotes M2 macrophage polarization, accelerating tumorigenesis and offering novel preclinical tools as well as potential therapeutic targets for lung cancer immunotherapy. Abstract The major clinical challenge in lung cancer immunotherapy is drug resistance. Therefore, … Read more

Impact of the adenosine receptor A2BR expressed on myeloid cells on immune regulation during pregnancy. [[{“value”:”Stefanie Dietz, Janine Hebel, Jessica Rühle, Alisha Huff, Holger K. Eltzschig, Trim Lajqi, Christian F. Poets, Christian Gille, Natascha Köstlin‐Gille”}]]

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The absence of adenosine receptor A2B on myeloid cells in Adora2B923f/f-LysMCre mice resulted in systemic changes in myeloid and lymphoid cell populations during pregnancy. There was an increased expression of IL-6 and a reduction of MDSC and uNK cells. However, there were only marginal differences in pregnancy outcomes. Abstract During pregnancy, the maternal immune system … Read more

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