European Journal of Immunology

Trametinib Suppresses the Stimulated T Cells Through G1 Arrest and Apoptosis. [[{“value”:”Toshimasa Nakao, Takero Shindo, Hideki Takakura, Takumi Narita, Yukako Ise‐Nakao, Saeko Akiyama, Yosuke Iizumi, Shogen Boku, Motoki Watanabe, Toshiyuki Sakai, Seiichi Shimizu, Masaki Yamada, Yoshihiro Sowa, Michihiro Mutoh”}]]

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Trametinib was originally developed as an anticancer reagent, but recent reports have suggested Trametinib may have potential as an immunosuppressant. Our data suggested that trametinib suppressed T-cell proliferation as well as cancer proliferation through G1 arrest and apoptosis. Trametinib suppressed CD4 and CD8 T cell proliferation by inducing G1 arrest and apoptosis along with suppression … Read more

BTK‐Inhibition Enhances TLR‐7‐Mediated Interferon‐Alpha Production in pDCs by Blocking the Inhibitory BDCA‐2 Pathway. [[{“value”:”Laura Ceglarek, Ramona Gerhards, Vinicius Boldrini, Christian Wichmann, Anneli Peters, Edgar Meinl”}]]

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In pDCs, BTK-inhibition (BTKi) blocks the IFN-α production via TLR-9, but not via TLR-7. Upon TLR-7 stimulation, BTKi enhances the production of IFN-α by blocking the inhibitory BDCA-2 pathway. This might explain partially the failure of BTKi in SLE and is of interest for BTKi trials in multiple sclerosis.

Towards the Next Generation of Data‐Driven Therapeutics Using Spatially Resolved Single‐Cell Technologies and Generative AI. [[{“value”:”Avital Rodov, Hosna Baniadam, Robert Zeiser, Ido Amit, Nir Yosef, Tobias Wertheimer, Florian Ingelfinger”}]]

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This review explores the technical advances in single-cell multi-omics technologies alongside the parallel development of generative AI tools to uncover biological insights. By integrating these innovative approaches, we highlight the potential to identify diagnostic, prognostic and outcome biomarkers, enhance patient stratification systems and discuss future prospects for advancing precision medicine and personalised therapeutic strategies. ABSTRACT … Read more

Cover Story: Eur. J. Immunol. 2’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

The Anti‐Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement‐Dependent Cytotoxicity of Human Leukocytes. [[{“value”:”Amal Elhage, Debbie Watson, Ronald Sluyter”}]]

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The anti-P2X7 monoclonal antibody (clone L4) mediates complement-dependent cytotoxicity of human leukocytes. This process preferentially targets leukocytes with high cell surface P2X7, such as monocytes and dendritic cells, presenting a new strategy to reduce P2X7 immune functions. ABSTRACT P2X7 is an extracellular adenosine 5′-triphosphate (ATP)-gated cation channel that plays various roles in inflammation and immunity. … Read more

The VEGF‐Mediated Cytoprotective Ability of MIF‐Licensed Mesenchymal Stromal Cells in House Dust Mite‐Induced Epithelial Damage. [[{“value”:”Hazel Dunbar, Ian J. Hawthorne, Courteney Tunstead, Molly Dunlop, Evelina Volkova, Daniel J. Weiss, Claudia C. dos Santos, Michelle E. Armstrong, Seamas C. Donnelly, Karen English”}]]

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Licensing of MSCs with MIF requires CXCR4 receptor binding. Enhanced VEGF production by MIF-licensed MSCs promotes wound healing in vitro and can be blocked using the VEGFR2 inhibitor SU-5416. MIF-licensed MSC conditioned medium significantly reduced goblet cell hyperplasia in house dust mite-driven allergic airway inflammation in vivo. ABSTRACT Enhancing mesenchymal stromal cell (MSC) therapeutic efficacy … Read more

Direct Inhibitory Effect of HTLV‐1‐Infected T Cells on the Production of Anti‐Ro/SS‐A Antibody by B Cells from Patients with Sjögren’s Syndrome. [[{“value”:”Kinya Nagata, Masako Tsukamoto, Yosuke Nagasawa, Noboru Kitamura, Hideki Nakamura”}]]

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HTLV-1-infected T-cell lines suppress IgG and autoantibody production from B cells of healthy donors and patients with Sjögren’s syndrome through cell-to-cell contact and some humoral factors. ABSTRACT The reasons for the low frequency of anti-Ro/SS-A antibody in patients with HTLV-1-associated myelopathy complicated with Sjögren’s syndrome (SS) are unclear. In this study, we investigated whether HTLV-1-infected … Read more

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