European Journal of Immunology

Probiotics administered to pregnant mice led to increased frequencies of IL17-committed Vγ6⁺ γδ T cells in the neonatal lung. This highlights a microbiota-sensitive pathway where maternal probiotics enhance γδ17 commitment in the perinatal lung. ABSTRACT The early life period is increasingly being recognized as a window of opportunity to shape immunity, where microbiota and related … Read more

A gluten-free diet prevents Type I diabetes in NOD mice. We characterized T cells from prediabetic mice on gluten-free or standard diets using flow cytometry and single-cell transcriptomics. A gluten-free diet enhanced T-cell activation and effector differentiation, including regulatory T cells, suggesting immune modulation as a mechanism for diabetes prevention. ABSTRACT Nonobese diabetic (NOD) mice … Read more

In children with chronic non-bacterial osteomyelitis, clinical and transcriptional changes in peripheral blood were examined after pamidronate treatment. Clinically effective treatment with pamidronate was associated with reduced expression of two genes (TRDV2 and TRGV9) that encode the subunits of the Vγ9Vδ2 T-cell receptor.

The evolution of the concept of the immune system from a set of composed cells and tissue that defend the host from exogenous agents into a system that has regulatory and homeostatic functions determined by the interaction with microorganisms as a functional part of an extended immune system, that we call symmunobiome. ABSTRACT The immune … Read more

The RNA-binding proteins ZFP36L1 and ZFP36L2 regulate in T cells the production of the key effector molecules TNF, IL-2, and IFNγ. Genetic deletion of ZFP36L1 and ZFP36L2 induces superior cytokine production in continuously activated tumor-infiltrating lymphocytes. However, ZFP36L1+ZFP36L2-deficient T cells exhibit reduced cell fitness: they more frequently undergo apoptosis, potentially due to disrupted cell cycle … Read more

Dimethyl fumarate (DMF) inhibits T-cell proliferation and induces apoptosis by depleting glutathione (GSH) and accumulating reactive oxygen species (ROS). Here, we show that DMF-induced oxidative stress disrupts multiple cell-signaling pathways, including MYC, leading to cell cycle arrest and impaired proliferative responses in activated T-cells. ABSTRACT Recent evidence indicates that the TCA cycle metabolite fumarate plays … Read more

The supernatant of M. tuberculosis-stimulated B cells promotes monocyte polarization toward an anti-inflammatory CD16⁺CD163⁺CD206⁺PD-L1⁺ phenotype via an IL-6/STAT3 pathway. Confirmed with B cells from TB patients, this pathway impairs monocyte proinflammatory functions and may contribute to immune suppression in tuberculosis. Created in BioRender. Neyrolles, O. (2025) https://BioRender.com/930ras3 ABSTRACT The polarization of the monocyte/macrophage compartment toward an … Read more

T-cell recognition of microbiota-derived epitopes is key to immune homeostasis. Here, we used an unbiased screening platform to identify novel immunogenic epitopes from Akkermansia muciniphila and Bacteroides thetaiotaomicron. We demonstrated that these epitopes are conserved across multiple other bacterial strains, suggesting their potential relevance in broader immune interactions. ABSTRACT Antigen-specific recognition of microbiota by T … Read more

Metabolic antagonism in the TME suppresses CD8+ T cell function by depleting essential nutrients and generating toxic byproducts. Metabolic symbiosis between tumor cells and TAMs fosters an immunosuppressive microenvironment. Disrupting metabolic interactions can overcome immune suppression, boost antitumor immunity, and enhance immunotherapy efficacy. ABSTRACT The fate of immune cells is fundamentally linked to their metabolic … Read more

Autoantibodies neutralizing Type I interferons increase the risk of severe viral diseases and are linked to autoimmune conditions. The automated VIDAS assay is suitable for anti-IFN-α2 IgGs quantification, offering a swift, reliable, user-friendly, single test for clinical management.