European Journal of Immunology

We found a reduced frequency of circulating mucosal-associated invariant T cells (MAITs) in patients with APECED with a clear negative correlation to inflammatory markers CRP, IL-18, and IFN-γ. These findings suggest that the decrease in MAITs is secondary to type 1 immune dysregulation present in the disease. Abstract Mucosal-associated invariant T cells (MAIT) are innate-like … Read more

This review summarizes the current knowledge about γδ T cells in immune-mediated kidney diseases. We highlight that γδ T cells are associated with an aggravation of tissue damage through direct pathways and interactions with other leukocyte subsets . Abstract Immune-mediated kidney diseases, including glomerulonephritis (GN), represent a diverse spectrum of disorders characterized by inflammation within … Read more

Our study reveals that high-dose UVB exposure stimulates Langerhans cells to release chemokines that recruit neutrophils and induce TNF-α-mediated apoptosis in DNA-damaged keratinocytes. Without Langerhans cells, fewer neutrophils are recruited, leading to an accumulation of DNA-damaged cells and a higher risk of skin cancer due to increased mutations and potential cell transformation. Abstract Ultraviolet (UV) … Read more

Low-dose IL-2 balances Tfh, Tph, and Treg cells in myasthenia gravis (MG), by increasing Treg cells and reducing Tfh and Tph cell populations in patients. The results provide in vitro evidence for the use of IL-2 as a potential therapeutic in MG. Abstract Follicular helper (Tfh), peripheral helper (Tph), and regulatory (Treg) T cells are … Read more

A review of lipid nanoparticle development and application for engineering T cells, NK cells, macrophages, dendritic cells, and stem cells for immunotherapies. Abstract Lipid nanoparticles (LNPs) have emerged as the preeminent nonviral drug delivery vehicles for nucleic acid therapeutics, as exemplified by their usage in the mRNA COVID-19 vaccines. As a safe and highly modular … Read more

After a hesitant start, the number of available therapeutics that target the human complement system has surged from one to a dozen drugs in less than 20 years. Meanwhile, the clinical arsenal encompasses treatment modalities directed to several targets for the therapy of a steadily growing spectrum of complement-related disorders. Abstract Therapeutic interventions in the … Read more

(Top). Representative protumorigenic GPCRs can regulate cancer at multiple levels, including immune cell recruitment to TME, angiogenesis, and tumor biology. (Bottom). Multiple and parallel targeting of selected protumorigenic GPCRs might overcome receptor redundancy and impede tumor growth on various fronts, thus increasing the therapeutic potential of GPCR-targeted therapies. Abstract G protein-coupled receptors (GPCRs) are vital … Read more

Older and obese individuals are at greater risk of developing severe COVID-19. In this paper, we identified that this may be related to decreased levels of testosterone and estradiol, by showing that these sex hormones reduce the excessive production of proinflammatory cytokines induced by anti-SARS-CoV-2 IgG antibodies. Abstract COVID-19, the disease caused by SARS-CoV-2, particularly … Read more

ThymoSpheres provide an innovative, user-friendly in vitro model for generating mature, predominantly CD8 single positive T cells. These cells resemble human polyclonal αβ unconventional T cells in transcriptome and TCR repertoire characteristics, making this model valuable for studying the development of this specific T-cell lineage. Abstract In vitro cultures remain crucial for studying the fundamental … Read more