European Journal of Immunology

Interferons and Cytokines Induce Transcriptional Activation of the Long‐Interspersed Element‐1 in Myeloid Cells from Autoimmune Patients. [[{“value”:”Ethan Le, Fatemeh Moadab, Xiaoxing Wang, Rayan Najjar, Sadie J. Van den Bogaerde, Alison Bays, John LaCava, Tomas Mustelin”}]]

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Patients with systemic lupus erythematosus (SLE) frequently have autoantibodies against the ORF1p protein encoded by the retrotransposon “long interspersed element-1” (LINE-1 or L1). Here, we report that type I interferon and other cytokines or toll-like receptor agonists induce a rapid increase in L1 transcripts and ORF1p in myeloid cells. ABSTRACT Approximately 17% of our genome … Read more

Age and Latent Cytomegalovirus Infection Do Not Affect the Magnitude of De Novo SARS‐CoV‐2‐Specific CD8+ T Cell Responses. [[{“value”:”Jet van den Dijssel, Veronique A. L. Konijn, Mariël C Duurland, Rivka de Jongh, Lianne Koets, Barbera Veldhuisen, Hilde Raaphorst, Annelies W. Turksma, Julian J. Freen‐van Heeren, Maurice Steenhuis, Theo Rispens, C Ellen van der Schoot, S. Marieke van Ham, Rene A. W. van Lier, Klaas P. J. M. van Gisbergen, Anja ten Brinke, Carolien E. van de Sandt”}]]

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Immunosenescence and cytomegalovirus infection are suggested to impair protective immunity against novel pathogens. Despite reduced total CD8+ Tnaïve cells in older CMV– and CMV+ individuals, our study found a broad and robust memory SARS-CoV-2-specific CD8+ T cell response in both younger and older convalescent COVID-19 donors regardless of CMV status. ABSTRACT Immunosenescence, age-related immune dysregulation, … Read more

A Critical Oversight in Immunology Research: The Prevalence of Complement Deficiencies in Mouse Models. África González‐Fernández

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Several mouse strains have a genetic deficiency in the fifth component of complement (C5). This defect affects research outcomes in areas such as allergies, autoimmunity, cancer, infectious diseases, and inflammation. ABSTRACT The complement system is a crucial component of the innate immune response, playing a vital role in defending the body against pathogens and maintaining … Read more

Vaginal Prevotella timonensis Bacteria Enhance HIV‐1 Uptake and Differentially Affect Transmission by Distinct Primary Dendritic Cell Subsets. [[{“value”:”Marleen Y. van Smoorenburg, Ester B. M. Remmerswaal, Celia Segui‐Perez, John L. van Hamme, Karin Strijbis, Teunis B. H. Geijtenbeek”}]]

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The bacterium Prevotella timonensis found in vaginal dysbiosis enhances the uptake of HIV-1 by primary dendritic cells. Virus is internalised into tetraspanin-rich compartments, which leads to efficient HIV-1 transmission to target cells. These results provide insight into how microbiota directly affect HIV-1 uptake thereby altering HIV-1 susceptibility. Created in BioRender. Geijtenbeek, T. (2025) https://BioRender.com/i89c292. ABSTRACT … Read more

Maximizing Insights, Minimizing Animal Testing: A Framework for Validating Multiparametric Single‐Cell Cytokine Analysis Panels. [[{“value”:”Johann Aleith, Wendy Bergmann‐Ewert, Brigitte Müller‐Hilke”}]]

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Multicolor spectral flow cytometry panels for cytokine expression analysis were optimized and validated without animal testing. Stimulated co-cultures of helper T cells, splenocytes, and fibroblast-like synoviocytes provided a complex cellular environment suitable for validating intracellular cytokine staining. This approach offers a more ethical alternative to commonly used animal disease models. ABSTRACT Intracellular cytokine labeling combined … Read more

Two New Kindreds with Complete Factor D Deficiency. [[{“value”:”Mathilde Puel, Kenza Rwayane, Paula Vieira Martins, Marwa Chbihi, Frédéric Rieux‐Laucat, Jérémie Rosain, Eric Jeziorski, Bertrand Boisson, Jean‐Laurent Casanova, Véronique Frémeaux‐Bacchi, Carine El Sissy”}]]

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The complement system plays a crucial role in immune defense, and factor D deficiency is a rare immunodeficiency associated with life-threatening bacterial infections. We report two new cases of complete factor D deficiency, including the first described in a Down syndrome patient, highlighting the need to investigate complement deficiencies in patients with secondary immunosuppression. Given … Read more

Cover Story: Eur. J. Immunol. 3’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

Survival and Developmental Progression of Unselected Thymocytes in the Absence of the T‐Cell Adaptor Gads. [[{“value”:”Rose Shalah, Manal Marzouk, Enas Hallumi, Naama Klopstock, Deborah Yablonski”}]]

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• We present a model for inducible deletion of Gads (GadsiKO), resulting in chimeric mice. • The relative frequency of Gads-deficient (red) thymocytes decreases at Gads-dependent developmental checkpoints. • Gads promotes death by neglect and suppresses the aberrant progression of unselected thymocytes to the CD4 SP compartment. ABSTRACT Thymocyte β-selection and positive-selection depend on TCR … Read more

VSTM1/SIRL‐1: An Inhibitory Pattern Recognition Receptor Regulating Myeloid Cells. [[{“value”:”Maaike Koops, Linde Meyaard”}]]

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VSTM1 is an inhibitory receptor expressed on myeloid cells recognizing endogenous and microbial ligands, classifying it as a pattern recognition receptor. During homeostasis, VSTM1 inhibits Fc-mediated reactive oxygen species (ROS) and neutrophil extracellular trap formation (NET) in granulocytes and monocytes. After activation of the Fc receptor by, for example, an infection, VSTM1 is downregulated and … Read more

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