European Journal of Immunology

This review introduces the “Epithelial Immunopharmacological Rheostat,” a framework where the respiratory epithelium calibrates immune tolerance versus inflammation through four interacting axes. Dysregulation of these axes drives chronic lung diseases, offering a roadmap for precision therapies that reset the rheostat. ABSTRACT The respiratory epithelium is a dynamic immunopharmacological interface that transcends its traditional role as … Read more

This study describes the generation of a recombinant IFNα2-BCMAext-GFP probe, which enables sensitive detection of BCMA-directed CAR-T cells. The probe efficiently identifies idecabtagene vicleucel (ide-cel) CAR-T cells in patients with multiple myeloma and provides a simple alternative to current BCMA-based detection reagents. ABSTRACT Chimeric antigen receptor (CAR)-T-based strategies target the B-cell maturation antigen (BCMA) expressed … Read more

Inflammaging is a chronic, low-grade, sterile inflammation associated with aging that contributes to age-related diseases and functional decline. Recent research suggests that targeting inflammaging through senolytics, metabolic modulators, microbiome-based interventions, and lifestyle modifications may help improve healthspan, reduce chronic disease burden, and promote healthy aging. ABSTRACT Inflammaging, defined as the persistent, low-grade sterile inflammation accompanying … Read more

Immunity to Trichuris muris infection is unimpacted by epithelial knockout of TSLP expression. Imaging of transcription in the caecum reveals Tslp transcription throughout infection in EpCAM-, Foxl1-, Ccl24- lamina propria-resident cells, contributing during the expulsion phase of infection. ABSTRACT Recent research examining classical type two alarmin TSLP has uncovered non-epithelial cellular sources of the cytokine … Read more

Our study describes how the effector maturation of intrathymic iNKT and MAIT cells is guided by distinct hematopoietic APCs: DC1s for iNKT cells and macrophages for MAIT cells. ABSTRACT The development of unconventional αβ T cells, including invariant natural killer T (iNKT) and mucosal-associated invariant T (MAIT) cells, in the thymus is distinct from conventional … Read more

Complement factor H is a central regulator of the complement system and thus a target for therapeutic intervention. In this review, we provide an overview of past and current factor H-based therapeutic concepts and modalities to treat complement-mediated diseases. ABSTRACT The complement system is a key component of innate immunity, modulating immunological processes to maintain … Read more

Immunological disturbances such as persistent activation of immune cells and reduced cytotoxicity by natural killer (NK) cells are reported as key aspects in post-COVID-19 condition (PCC). Our findings provide new evidence of altered passive and TRPM3-mediated Ca2+ influx, significantly impacting cytoplasmic and mitochondrial Ca2+ mobilization in PCC. ABSTRACT According to the World Health Organization (WHO), … Read more

This review examines how a high-salt diet disrupts gut microbiota composition, impairs intestinal barrier integrity, and modulates macrophage function, with a focus on their interconnection along the gut-liver axis. It highlights key methodological challenges, summarizes current mechanistic understanding, and identifies critical gaps for future research. ABSTRACT The Global North is increasingly exposed to a Western … Read more

Pam3CSK4 amplifies aPL-induced monocyte activation. This results in thromboinflammatory activation that may contribute to APS-related vascular pathology. ABSTRACT Antiphospholipid antibodies (aPL) are drivers of inflammation and thrombosis in antiphospholipid syndrome (APS). However, the molecular mechanisms underlying infection-induced exacerbation of APS remain incompletely understood. To identify novel pathways contributing to the pro-inflammatory and pro-coagulant activation of … Read more

European Journal of Immunology, Volume 56, Issue 7, July 2026.