European Journal of Immunology

Here, we studied the impact of myeloid cell depletion on atherosclerosis in Apoe − /− mice using a Macrophage Fas-induced apoptosis (MaFIA) mouse model. MaFIA mice carry an inducible apoptosis gene under the control of the Csf1r promotor, enabling specific and transient depletion of Csf1r-expressing cells. Upon systemic induction of apoptosis, plaque macrophage and smooth … Read more

T-cell-derived lymphotoxins promoted IL-17A+ and GM-CSF+ responses at disease onset. At peak EAE, ILC3-derived lymphotoxins inhibited the infiltration of IFN-ɣ- and GM-CSF-producing CD4+ T cells into the CNS, while T-cell-derived lymphotoxins limited Treg accumulation. B-cell-derived lymphotoxins promoted type 1 cytokine production by T cells in rhMOG1–125-induced EAE. Abstract Lymphotoxin α and lymphotoxin β (LTs), TNF … Read more

Immune-adipose-metabolism factors in the macro- and micro-breast-tumour environment are influenced by the magnitude of surgery and certain clinicopathological features. These results provide insight into the complex immune processes of the peri-operative period. Abstract Surgical resection is the primary treatment approach for patients with breast cancer. Despite optimal multimodal treatment, metastatic recurrence remains a risk. Surgery-mediated … Read more

Schematic diagram of ATG16L2-mediated NLRC4 inflammasome activation during Salmonella typhimurium infection. After NAIPs recognize the different components of S. typhimurium, ATG16L2 promotes the binding of NAIPs to NLRC4, enhancing the oligomerisation of ASC and the subsequent caspase-induced cleavage of IL-1β and GSDMD. N-terminal perforates the cell membrane, causing pyroptosis and LDH leakage. Abstract As cytoplasmic … Read more

Dectin-1 is a C-type lectin receptor for the innate sensing of fungi. This receptor exists in two major isoforms in mice differing in a stalk domain, which determines their degradative pathway. Here, we characterise the properties of the two isoforms in a cellular context and using a newly established in vivo model. Abstract Dectin-1 is … Read more

In the K/BxN arthritis mouse model, Nr1h2/3−/− animals showed exacerbated arthritis, histologic inflammation and joint destruction, and increased synovial metalloproteases, IL-1β and CCL2 in joints compared with wild-type animals. In FLS from RA patients, LXR agonists inhibited cell proliferation and collagenase activity in response to TNF, chemokine-induced migration, and CXCL12 production. Abstract The role of … Read more

After exposure to LPS, Alveolar macrophages (AMs) secrete TNF-α to induce GM-CSF production by alveolar epithelial cells (AECs). GM-CSF promotes AMs to secrete IL-6 and primes AMs for subsequent challenges. These results show that in response to MAMP stimulation, AMs and AECs respond collaboratively and AMs are primed. Abstract Alveolar macrophages (AMs) are sentinels in … Read more

We investigated sodium lauryl sulfate (SLS)-skin reactions because of its relevance in patch tests of patients, and we compared its effects with ACD-inducing oxazolone (OXA) and ICD-inducing croton oil (CrO). SLS-induced contact dermatitis differed from classical ACD and ICD, as it elicited less pronounced immune alterations. Abstract Sodium lauryl sulfate (SLS) is used as a … Read more

European Journal of Immunology, EarlyView.

Both animal and human studies have indicated the importance of MIF and CD74 in traumatic SCI. This review discusses how the MIF/CD74 axis affects numerous cell types and recovery post-SCI and proposes a new path for investigation focused on B cells. Abstract Traumatic spinal cord injury (SCI) is a severe condition leading to long-term impairment … Read more