European Journal of Immunology – Page 39

Cytokine Autoantibodies Alter Gene Expression Profiles of Healthy Donors. [[{“value”:”Jakob Hjorth von Stemann, Florian Dubois, Violaine Saint‐André, Vincent Bondet, Celine Posseme, Bruno Charbit, Lluis Quintana‐Murci, Morten Bagge Hansen, Sisse Rye Ostrowski, Darragh Duffy, Milieu Intérieur Consortium”}]]

19 de November de 2024 by

Working on the 1000-donor Milieu Interieur cohort with ex vivo whole blood stimulation, we demonstrate that naturally occurring cytokine autoantibodies (c-aAb) in healthy donors can neutralize cytokine availability and regulate proinflammatory gene expression. ABSTRACT Autoantibodies against cytokines (c-aAb) have been implicated in the pathophysiology of autoimmune diseases, and a variety of infections. In addition, several … Read more

The Microbiome Modifies Manifestations of Hemophagocytic Lymphohistiocytosis in Perforin‐Deficient Mice. [[{“value”:”Jasmin Mann, Solveig Runge, Christoph Schell, Katja Gräwe, Gudrun Thoulass, Jessica Lao, Sandra Ammann, Sarah Grün, Christoph König, Sarah A. Berger, Benedikt Hild, Peter Aichele, Stephan P. Rosshart, Stephan Ehl”}]]

17 de November de 2024 by

This study investigates the microbiome as a potential factor underlying the apparent differences in immune stimulation required for HLH induction in perforin-deficient mice compared to FHL-2 patients. Using PKO-Wildlings, we show that while immune activation by natural microbiota is not sufficient to induce HLH, it can influence manifestations of LCMV-induced disease. ABSTRACT Primary hemophagocytic lymphohistiocytosis … Read more

Neural Crest‐Derived Mesenchymal Cells Support Thymic Reconstitution After Lethal Irradiation. [[{“value”:”Doris Narki Tetteh, Kana Isono, Mari Hikosaka‐Kuniishi, Hidetoshi Yamazaki”}]]

17 de November de 2024 by

Thymic NC-derived mesenchymal cells produce factors, including Flt3L and Periostin, after irradiation. Depletion of NC-derived mesenchyme reduces these factors, decreases the abundance of ETPs, and impairs thymic reconstitution postirradiation. The addition of Flt3L and Periostin after NC-derived mesenchyme depletion restores reconstitution, highlighting the importance of NC-derived mesenchyme in thymus regeneration. ABSTRACT Reconstitution of the thymus … Read more

Type I Interferon Drives a Cellular State Inert to TCR‐Stimulation and Could Impede Effective T‐Cell Differentiation in Cancer. [[{“value”:”Dillon Corvino, Martin Batstone, Brett G. M Hughes, Tim Kempchen, Susanna S Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally Pearson, Jason Madore, Lambross T. Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, Michael Hölzel, Nicholas Borcherding, Matthias Braun, Tobias Bald”}]]

12 de November de 2024 by

Multimodal single-cell RNA sequencing identified a population of CD8+ T cells elevated in tumor tissue enriched for interferon-stimulated genes (ISG). These ISG cells are clonally related to a population of Granzyme K (GZMK)-expressing CD8+ T cells. However, unlike GZMK-expressing T cells, ISG cells were transcriptionally inert in response to in vitro stimulation. Created in BioRender.com … Read more

B Cells With Complementary B Cell Receptors Can Kill Each Other. [[{“value”:”Ramakrishna Prabhu Gopalakrishnan, Marius Sigurdsson Østrøm, Frode Miltzow Skjeldal, Oddmund Bakke, Bjarne Bogen, Peter Csaba Huszthy”}]]

10 de November de 2024 by

Depending on whether the interactions occur in vitro or in vivo, physical binding between two B cells with complementary BCRs leads to distinct outcomes for the participating cells. In vitro, both the Id+ B cell and the complementary anti-idiotypic B cell undergo apoptosis. In vivo, follicular αId B cells expand, whereas marginal zone Id+ B … Read more

Characterization of the Molecular Signature of Human Monocytes in Aging and Myelodysplastic Neoplasms. [[{“value”:”Christina Maria Rimpa, Maria Grigoriou, Athanasios Tasis, Nikolaos Paschalidis, Anastasia Filia, Giannis Vatsellas, Panagiotis Papazoglou, Antonios Chatzigeorgiou, Chrysa Kymparidou, Menelaos Papoutselis, Christina Misidou, Theodoros Spyropoulos, Despoina Dimitriou, Haralampos Hatzikirou, Konstantinos Liapis, Eleftheria Lamprianidou, Ioannis Kotsianidis, Ioannis Mitroulis”}]]

9 de November de 2024 by

• Aging leads to chronic inflammation and immune dysfunction, heightening the risk of myeloid malignancies like MDS and CMML. • Both aging and MDS show alterations in monocyte subtypes and function. Aging boosts inflammatory genes upregulation, whereas MDS favors antigen presentation, reflecting distinct immune and disease-specific adaptations. • MDS shows reduced inflammatory activity in CD14+ … Read more

Rise of a CD27− IgD− CD11c+ B cells population in kidney recipients achieving long‐term graft stability under immunosuppression. [[{“value”:”François Brinas, Nicolas Sailliet, Gaëlle Tilly, Laurence Delbos, Clarisse Kerleau, Magali Giral, Nicolas Degauque, Sophie Brouard, Richard Danger”}]]

8 de November de 2024 by

We performed a comprehensive blood phenotyping in 24 kidney-transplanted patients and 10 healthy volunteers. Among numerous immune cell subsets, mainly differences in B-cell populations were highlighted, with an increase of CD11c+ memory B cells in blood from kidney transplanted patients with long-term posttransplantation time. Abstract The use of immunosuppressive treatment is required to prevent rejection … Read more

Neutrophil Extracellular Traps Participate in the Pathogenesis of Lupus Through S100A10‐Mediated Regulatory T‐Cell Differentiation and Functional Abnormalities. [[{“value”:”Hua Guo, Qian Liang, Zhonghui Xue, Junling Yang, Pengyu Chen, Juan Ji, Jing Li, Genkai Guo, Haixia Cao, Xiaoqi Sha, Rui Zhao, Chen Dong, Zhifeng Gu”}]]

8 de November de 2024 by

Neutrophil extracellular traps (NETs) contribute to SLE development, yet their interaction with Regulatory T cells (Tregs) remains obscure. This study reveals that selectively enhanced NETs in mice suppress Treg production and function. Through modulating naive CD4+ T cells via TLR4, NETs inhibit Treg differentiation, bridging innate and adaptive immune responses. ABSTRACT In systemic lupus erythematosus … Read more

Circulating levels of endogenous complement inhibitors correlate inversely with complement consumption in systemic lupus erythematosus. [[{“value”:”Stef van der Meulen, Rory C. Monahan, Kyra A. Gelderman, Cees van Kooten, Y.K. Onno Teng, Tom W.J. Huizinga, Gerda M. Steup‐Beekman, Leendert A. Trouw”}]]

8 de November de 2024 by

Complement activation is a distinct feature of (neuropsychiatric) systemic lupus erythematosus. However, little is known about complement regulation by endogenous soluble complement inhibitors. We show differences in serum levels between (NP)SLE patients and healthy controls, but regulator levels are not discriminative between NPSLE and SLE. Created with Biorender.com. Abstract Systemic lupus erythematosus (SLE) is marked … Read more

Correct stimulation of CD28H arms NK cells against tumor cells. [[{“value”:”Raphaëlle Leau, Pierre Duplouye, Virginie Huchet, Véronique Nerrière‐Daguin, Bernard Martinet, Mélanie Néel, Martin Morin, Richard Danger, Cécile Braudeau, Régis Josien, Gilles Blancho, Fabienne Haspot”}]]

8 de November de 2024 by

Targeting CD28H with a properly selected antibody activates NK cells by increasing their cytotoxicity and overcoming inhibitory signals. ScRNA-seq analysis of ccRCC shows that CD28H+ NK cells infiltrate HHLA2+ tumors and could be effectively targeted by this antibody thus offering a promising approach for enhancing antitumor responses. Abstract Tumor evasion has recently been associated with … Read more