European Journal of Immunology

AK2‐Deficient Mice Recapitulate Impaired Lymphopoiesis of Reticular Dysgenesis Patients, but Also Lack Erythropoiesis. [[{“value”:”Rebekka Waldmann, Franziska Werner, Alpaslan Tasdogan, Felix Immanuel Maier, Ursula Kohlhofer, Irene Gonzalez‐Menendez, Leticia Quintanilla de Fend, Amrit Kaur Puarr, Ruth Maree Arkell, Anselm Enders, Manfred Hoenig, Hubert Schrezenmeier, Hans Joerg Fehling, Klaus Schwarz, Ulrich Pannicke”}]]

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Ak2 deficiency leads to impaired development of T and B cells in mice, corresponding to impaired lymphopoiesis of reticular dysgenesis (AK2 deficiency) in humans. In contrast to the human pathophysiology, Ak2 deficiency is lethal in mice due to severe anaemia, and murine myelopoiesis is less affected. ABSTRACT Reticular dysgenesis (RD) is a rare genetic disorder … Read more

Human Type‐I Interferon Omega Holds Potent Antiviral Properties and Promotes Cytolytic CD8+ T Cell Responses. [[{“value”:”Hoang Oanh Nguyen, Patricia Recordon Pinson, Marie‐Line Andreola, Laura Papagno, Victor Appay”}]]

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Human interferon-ω (IFN-ω) is produced by monocytes and plasmacytoid dendritic cells in response to inflammatory stimuli. It confers antiviral protection to lung epithelial cells against SARS-CoV-2 infection and enhances the effector functions of antigen-specific CD8⁺ T cells. ABSTRACT The type-I interferon family is well known for its critical role in innate immunity. It comprises several … Read more

Cover Story: Eur. J. Immunol. 7’25.

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Our cover features images related to flow cytometry techniques widely used for analysis of function and phenotypes of major human and murine immune cell subsets, superimposed on a multidimensional immune cell population scatter plot. These images are taken from the third edition of EJI’s Flow Cytometry Guidelines by Cossarizza et al., a comprehensive resource prepared … Read more

nuTCRacker: Predicting the Recognition of HLA‐I–Peptide Complexes by αβTCRs for Unseen Peptides. [[{“value”:”Justin Barton, Trupti Gore, Meghna Phanichkrivalkosil, Adrian Shepherd, Michele Mishto”}]]

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nuTCRacker aims to predict unseen αβTCR-peptide-HLA-I affinity. Predictions are successful for only a subset of unseen peptides although they are better than the benchmarked methods. Predictions are tested on both novel and published T cell assays. ABSTRACT The ability to predict which antigenic peptide(s) the αβTCR of a given CD8+ T-cell clone can recognise would … Read more

Immunological and Clinical Markers of Post‐acute Sequelae of COVID‐19: Insights from Mild and Severe Cases 6 Months Post‐infection. [[{“value”:”William Mouton, Sophia Djebali, Marine Villard, Omran Allatif, Cécile Chauvel, Sarah Benezech, Philippe Vanhems, Jacqueline Marvel, Thierry Walzer, Sophie Trouillet‐Assant”}]]

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In this study of 458 patients post-COVID-19, nearly half developed postacute sequelae (PASC). While humoral and inflammatory markers were tied to COVID-19 severity, not PASC itself, individuals with PASC showed distinct T cell alterations, especially terminally differentiated, SARS-CoV-2-specific CD4+ T cells. A machine learning model identified T cell phenotypes as key PASC predictors. ABSTRACT Post-acute … Read more

Acellular Pertussis Vaccines Induce CD8+ and CD4+ Regulatory T Cells That Suppress Protective Tissue‐Resident Memory CD4+ T Cells, in Part via IL‐10. [[{“value”:”Caitlín Ní Chasaide, Pauline Schmitt, Béré K. Diallo, Lisa Borkner, Charlotte M. Leane, Seyed Davoud Jazayeri, Sreeram Udayan, Eoin O’Neill, Lucy M. Curham, Barry Moran, Mieszko M. Wilk, Kingston H. G. Mills”}]]

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The authors demonstrate that current aP vaccines induce IL-10-secreting CD4+ and CD8+ Treg cells that suppress IL-17-secreting respiratory tissue-resident memory (TRM) cells, and thereby fail to prevent nasal infection with B. pertussis. Blocking IL-10R in vivo or adding a novel adjuvant LP-GMP and intranasal delivery reverses suppression and enhances vaccine efficacy. Created with BioRender.com. ABSTRACT … Read more

γδ T Cells and Inborn Errors of Immunity. [[{“value”:”Sagar, Stephan Ehl”}]]

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This review examines inborn errors of immunity (IEIs) affecting γδ T cells, focusing on conditions that lead to their altered balance with αβ T cells. It highlights key molecular players and species differences in human and mouse models, offering insights into γδ T cell development and function with potential diagnostic and therapeutic implications. ABSTRACT Gamma … Read more

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