Can bacteria that breach mucosal barriers drive long-lasting changes in immunity? In this issue of Immunity, Robles-Vera et al. describe how, in the context of colitis, bacteria breaching the intestinal barrier reprogram precursors in the bone marrow v…
In a recent work reported in Science, Zhang et al. untangle dynamic changes arising across aging in multiple cell populations within thirteen organs using single-cell transcriptomics and identify four distinct dynamic waves in which immune cells are th…
The enteric nervous system is a key regulator of inflammation, crosstalking directly with the immune system at the mucosal surfaces of the gastrointestinal tract. In this issue of Immunity, Wang and colleagues demonstrate that intrinsic enteric neurons…
Indirect CD4+ T cell indirect allorecognition of donor peptides presented by host MHC class II antigens contributes to transplant rejection in part by eliciting donor-specific antibodies (DSAs). In this issue of Immunity, Zhanzak et al. revisit the rol…
Renowned for driving interferon responses, the cGAS-STING pathway reveals a surprising role: lysosomal biogenesis. In this issue of Immunity, Xu et al. uncover how STING activates the transcription factor TFEB, linking innate immune sensing to enhanced…
Generating genetically engineered mouse strains for in vivo studies can be a challenging and lengthy process. Nyberg, Wang, Ark, et al. present a method for gene transfer to mouse T cells in vivo using an evolved adeno-associated virus variant and demo…
Despite its range of disease associations, Epstein-Barr virus (EBV) treatments or vaccines are lacking. Joyce et al. determined EBV gp350 structures complexed with either its human receptor, CR2, or virus-neutralizing antibodies (nAbs), thus illustrati…
Jaschke and Wang review the current understanding of leukocyte compartmentalization in homeostasis and upon organismal stress, how neuroendocrine signals organize this trafficking, and the mechanisms underlying the functional diversification of leukocy…
How NLRP3 impacts Alzheimer’s disease (AD) is unclear. McManus et al. find that NLRP3 is located at mitochondria where it regulates microglial metabolism. Depletion or chronic pharmacological inhibition of NLRP3 increases glutamine utilization and α-ke…
Thymic injury leads to reduced T cell production and makes patients more vulnerable to infections and cancers. Lemarquis et al. identify a population of recirculating regulatory T (Treg) cells that mediate regeneration in the injured thymus, partially …
