Recent studies highlight the role of neurons in regulating anti-helminth immune responses, suggesting that intrinsic enteric neurons (iENs) may orchestrate intestinal immunity. Wang and Zhang et al. show that iENs sense helminth infection-induced ILC2 …
The lack of well-defined indirect CD4+ T cell epitopes has hindered mechanistic studies and the development of antigen-specific tolerance strategies in transplantation. Zhanzak et al. identify donor-derived CD4+ T cell epitopes associated with rejectio…
Common genetic variants in a cis-regulatory element at HDAC9, which regulates expression of the histone deacetylase HDAC9, are a major risk factor for cardiovascular disease. Asare et al. define a mechanism whereby HDAC9 regulates activation of the NLR…
scRNA-seq has uncovered ontogenically distinct hepatic macrophage populations, but their functions remain unclear. Here, De Ponti et al. identify recruited LAMs and resident LAM-like KCs in multiple liver injury models and reveal that TREM2 expression …
Robles-Vera et al. unveil the capacity of gut microbiota translocation, particularly Enterococcus faecalis, to mediate a Mincle-dependent induction of trained immunity in myeloid bone marrow progenitors. This can be protective against subsequent infect…
(Immunity 57, 2380–2398.e1–e6; October 8, 2024)
Cryoglobulinemic vasculitis is a common complication of HCV infection. Young et al. reveal that three categories of somatic mutagenesis converge on a single B cell to generate pathogenic, autoantibody-producing clones in this virus-induced autoimmune d…
Inhibiting T cell exhaustion is an attractive cancer immunotherapy strategy. In this issue of Immunity, Waibl Polania et al. examine the microenvironmental signals regulating terminal T cell exhaustion and find that antigen presentation by tumor-associ…
Immune activation during sustained stress typically worsens stress-related psychopathology. Whether it can enhance stress resilience remains unclear. In this issue of Immunity, Xia, Lu, Lan et al. uncover an anxiolytic function of intestinal IL-22 path…
The mechanisms underpinning susceptibility to influenza virus infection, resulting in life-threatening disease, are not well understood. In this issue of Immunity, Chakraborty et al. demonstrate that sialylated IgG suppresses NF-κB-driven inflammatory …
